Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits

J Sharifi-Rad, C Quispe, M Imran, A Rauf… - Oxidative medicine …, 2021 - Wiley Online Library
Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L.
and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein …

Using ncRNAs as tools in Cancer diagnosis and treatment—the way towards personalized medicine to improve patients' health

R Piergentili, G Basile, C Nocella, R Carnevale… - International journal of …, 2022 - mdpi.com
Although the first discovery of a non-coding RNA (ncRNA) dates back to 1958, only in recent
years has the complexity of the transcriptome started to be elucidated. However, its …

[HTML][HTML] Phytoestrogens and breast cancer: In vitro anticancer activities of isoflavones, lignans, coumestans, stilbenes and their analogs and derivatives

P Basu, C Maier - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Breast cancer is one of the leading causes of cancer-related morbidity and mortality among
women worldwide. Phytoestrogens, plant-derived polyphenols that structurally and …

Dietary phytochemicals as epigenetic modifiers in cancer: Promise and challenges

E Shankar, R Kanwal, M Candamo, S Gupta - Seminars in cancer biology, 2016 - Elsevier
The influence of diet and environment on human health has been known since ages. Plant-
derived natural bioactive compounds (phytochemicals) have acquired an important role in …

Role of phytonutrients in nutrigenetics and nutrigenomics perspective in curing breast cancer

T Bhattacharya, S Dutta, R Akter, MH Rahman… - Biomolecules, 2021 - mdpi.com
Breast cancer (BC) is one of the most common type of cancer and an important contributor to
female mortality. Several genes and epigenetic modifications are involved in the …

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

Z Javed, K Khan, J Herrera-Bravo, S Naeem… - Cancer Cell …, 2021 - Springer
Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors.
Research spanning over several decades has provided better understanding of complex …

Natural compounds modulate the crosstalk between apoptosis-and autophagy-regulated signaling pathways: Controlling the uncontrolled expansion of tumor cells

C Braicu, O Zanoaga, AA Zimta, AB Tigu… - Seminars in Cancer …, 2022 - Elsevier
Due to the high number of annual cancer–related deaths, and the economic burden that this
malignancy affects today's society, the study of compounds isolated from natural sources …

Inhibition of Cancer Development by Natural Plant Polyphenols: Molecular Mechanisms

A Lyubitelev, V Studitsky - International Journal of Molecular Sciences, 2023 - mdpi.com
Malignant tumors remain one of the main sources of morbidity and mortality around the
world. A chemotherapeutic approach to cancer treatment poses a multitude of challenges …

Dietary intervention by phytochemicals and their role in modulating coding and non-coding genes in cancer

L Budisan, D Gulei, OM Zanoaga, AI Irimie… - International journal of …, 2017 - mdpi.com
Phytochemicals are natural compounds synthesized as secondary metabolites in plants,
representing an important source of molecules with a wide range of therapeutic applications …

Genistein, a potential phytochemical against breast cancer treatment-insight into the molecular mechanisms

M Sohel, P Biswas, M Al Amin, MA Hossain, H Sultana… - Processes, 2022 - mdpi.com
Breast cancer (BC) is one of the most common malignancies in women. Although
widespread successful synthetic drugs are available, natural compounds can also be …