[HTML][HTML] Large-scale deep learning identifies the antiviral potential of PKI-179 and MTI-31 against coronaviruses

D van der Horst, ME Carter-Timofte, A Danneels… - Antiviral Research, 2024 - Elsevier
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to the
global pandemic of Coronavirus Disease (2019)(COVID-19), underscoring the urgency for …

Low selectivity indices of ivermectin and macrocyclic lactones on SARS-CoV-2 replication in vitro

C Chable-Bessia, C Boullé, A Neyret, J Swain… - Covid, 2022 - mdpi.com
Ivermectin was first approved for human use as an endectocide in the 1980s. It remains one
of the most important global health medicines in history and has recently been shown to …

Antiparasitic drugs against SARS-CoV-2: a comprehensive literature survey

E Calvo-Alvarez, M Dolci, F Perego, L Signorini… - Microorganisms, 2022 - mdpi.com
More than two years have passed since the viral outbreak that led to the novel infectious
respiratory disease COVID-19, caused by the SARS-CoV-2 coronavirus. Since then, the …

Ivermectin does not protect against SARS-CoV-2 infection in the Syrian hamster model

CS Foo, R Abdelnabi, L Vangeel, S De Jonghe… - Microorganisms, 2022 - mdpi.com
Ivermectin, an FDA-approved antiparasitic drug, has been reported to have in vitro activity
against SARS-CoV-2. Increased off-label use of ivermectin for COVID-19 has been reported …

Lack of antiviral activity of ivermectin against foot-and-mouth disease virus serotype O in BALB/c mice

S Arshad, S Raza, R Rafique, I Altaf, A Sattar - Microbial Pathogenesis, 2023 - Elsevier
Ivermectin is an FDA approved drug and showed in vitro antiviral activity against different
serotypes of Foot-and-mouth disease virus (FMDV). We here assessed the effect of …

[HTML][HTML] Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

RT Eastman, R Rusinova, KF Herold, XP Huang… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Since it was proposed as a potential host-directed antiviral agent for SARS-CoV-2, the
antiparasitic drug ivermectin has been investigated thoroughly in clinical trials, which have …

Repurposing Selamectin as an Antimicrobial Drug against Hospital-Acquired Staphylococcus aureus Infections

V Folliero, F Dell'Annunziata, B Santella, E Roscetto… - Microorganisms, 2023 - mdpi.com
The emergence of multidrug-resistant strains requires the urgent discovery of new
antibacterial drugs. In this context, an antibacterial screening of a subset of anthelmintic …

Comparative study of SARS-CoV-2 infection in different cell types: Biophysical-computational approach to the role of potential receptors

L González-Paz, MJ Alvarado, ML Hurtado-León… - Computers in biology …, 2022 - Elsevier
Cellular susceptibility to SARS-CoV-2 infection in the respiratory tract has been associated
with the ability of the virus to interact with potential receptors on the host membrane. We …

Biophysical Analysis of Potential Inhibitors of SARS-CoV-2 Cell Recognition and Their Effect on Viral Dynamics in Different Cell Types: A Computational Prediction …

L González-Paz, C Lossada, ML Hurtado-León… - ACS …, 2024 - ACS Publications
Recent reports have suggested that the susceptibility of cells to SARS-CoV-2 infection can
be influenced by various proteins that potentially act as receptors for the virus. To investigate …

Published benefits of ivermectin use in Itajaí, Brazil for COVID-19 infection, hospitalisation, and mortality are entirely explained by statistical artefacts

R Mills, AC Peçanha Antonio, G Tucker-Kellogg - medRxiv, 2023 - medrxiv.org
Background Two recent publications by Kerr et al.(Cureus 14 (1): e21272; Cureus 14 (8):
e28624) reported dramatic effects of prophylactic ivermectin use for both prevention of …