Ace revisited: a new target for structure-based drug design
KR Acharya, ED Sturrock, JF Riordan… - Nature Reviews Drug …, 2003 - nature.com
Current-generation angiotensin-converting enzyme (ACE) inhibitors are widely used for
cardiovascular diseases, including high blood pressure, heart failure, heart attack and …
cardiovascular diseases, including high blood pressure, heart failure, heart attack and …
Thymosin β4: actin-sequestering protein moonlights to repair injured tissues
AL Goldstein, E Hannappel, HK Kleinman - Trends in molecular medicine, 2005 - cell.com
Here, we review the biochemical and molecular properties of thymosin β 4 (Tβ 4), the major
actin-sequestering molecule in eukaryotic cells, and its key role in dermal-and corneal …
actin-sequestering molecule in eukaryotic cells, and its key role in dermal-and corneal …
N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin
YH Liu, M D'Ambrosio, T Liao, H Peng… - American Journal …, 2009 - journals.physiology.org
Galectin-3 (Gal-3) is secreted by activated macrophages. In hypertension, Gal-3 is a marker
for hypertrophic hearts prone to develop heart failure. Gal-3 infused in pericardial sac leads …
for hypertrophic hearts prone to develop heart failure. Gal-3 infused in pericardial sac leads …
Marine collagen: Unveiling the blue resource-extraction techniques and multifaceted applications
I Laasri, M Bakkali, L Mejias, A Laglaoui - International Journal of Biological …, 2023 - Elsevier
Marine organisms such as fish and shellfish are composed of compounds with properties
and characteristics that have been proven useful in a variety of sectors such as cosmetics …
and characteristics that have been proven useful in a variety of sectors such as cosmetics …
Signaling by the angiotensin-converting enzyme
I Fleming - Circulation research, 2006 - Am Heart Assoc
Inhibition of the angiotensin-converting enzyme (ACE) protects against the progression of
several cardiovascular diseases. Because of its dual role in regulating angiotensin II and …
several cardiovascular diseases. Because of its dual role in regulating angiotensin II and …
Angiotensin-converting enzyme inhibitors: a new mechanism of action
H Peng, OA Carretero, N Vuljaj, TD Liao, A Motivala… - Circulation, 2005 - Am Heart Assoc
Background—Angiotensin-converting enzyme (ACE) inhibitors are valuable agents for the
treatment of hypertension, heart failure, and other cardiovascular and renal diseases. The …
treatment of hypertension, heart failure, and other cardiovascular and renal diseases. The …
Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage
High blood pressure (HBP) is an important risk factor for cardiac, renal, and vascular
dysfunction. Excess inflammation is the major pathogenic mechanism for HBP-induced …
dysfunction. Excess inflammation is the major pathogenic mechanism for HBP-induced …
Ac-SDKP reverses inflammation and fibrosis in rats with heart failure after myocardial infarction
F Yang, XP Yang, YH Liu, J Xu, O Cingolani… - …, 2004 - Am Heart Assoc
Inflammation may play an important role in the pathogenesis of cardiac fibrosis in heart
failure (HF) after myocardial infarction (MI). N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is …
failure (HF) after myocardial infarction (MI). N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is …
Treatment of congestive heart failure: interfering the aldosterone-cardiac extracellular matrix relationship
Cardiac extracellular matrix undergoes extensive and continuous turnover involved in the
lesion-reparation process, such as in cardiac remodeling, in hypertensive cardiac …
lesion-reparation process, such as in cardiac remodeling, in hypertensive cardiac …
Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP
MA Cavasin, NE Rhaleb, XP Yang, OA Carretero - Hypertension, 2004 - Am Heart Assoc
N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a ubiquitous tetrapeptide hydrolyzed
almost exclusively by angiotensin-converting enzyme (ACE). Chronic treatment with Ac …
almost exclusively by angiotensin-converting enzyme (ACE). Chronic treatment with Ac …