Babesiosis is a disease with a world-wide distribution affecting many species of mammals
principally cattle and man. The major impact occurs in the cattle industry where bovine …

With advances in sequencing technology, uncharacterized proteins and domains of
unknown function (DUFs) are rapidly accumulating in sequence databases and offer an …

Successful control of falciparum malaria depends greatly on treatment with artemisinin
combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged …

The proteasome is a multi-component protease complex responsible for regulating key
processes such as the cell cycle and antigen presentation. Compounds that target the …

As the central figure of the cellular protein degradation machinery, the proteasome is critical
for cell survival. Having been extensively targeted for inhibition, the constitutive proteasome …

New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …

Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …

Gliotoxin (GT) is the most important epidithiodioxopiperazine (ETP)‐type fungal toxin. GT
was originally isolated from T richoderma species as an antibiotic substance involved in …

One in four proteins in Plasmodium falciparum contains asparagine repeats. We probed the
function of one such 28-residue asparagine repeat present in the P. falciparum proteasome …

Ribosome-targeting antibiotics exert their antimalarial activity on the apicoplast of the
malaria parasite, an organelle of prokaryote origin having essential metabolic functions …