[HTML][HTML] BRCA genes: the role in genome stability, cancer stemness and therapy resistance
I Gorodetska, I Kozeretska, A Dubrovska - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …
regulating genome integrity, cell division and death. The integrity of cellular genome is …
Cancer of the ovary
SA Cannistra - New England Journal of Medicine, 2004 - Mass Medical Soc
Patients with ovarian cancer usually present with advanced disease, and the disease is
generally managed with surgical resection followed by platinum-based chemotherapy …
generally managed with surgical resection followed by platinum-based chemotherapy …
BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation–Positive Women With Ovarian Cancer: A Report From the Australian Ovarian …
K Alsop, S Fereday, C Meldrum, A DeFazio… - Journal of clinical …, 2012 - ascopubs.org
Purpose The frequency of BRCA1 and BRCA2 germ-line mutations in women with ovarian
cancer is unclear; reports vary from 3% to 27%. The impact of germ-line mutation on …
cancer is unclear; reports vary from 3% to 27%. The impact of germ-line mutation on …
Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 …
N Mavaddat, D Barrowdale, IL Andrulis… - … Biomarkers & Prevention, 2012 - AACR
Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …
[图书][B] Perez & Brady's principles and practice of radiation oncology
EC Halperin, LW Brady, CA Perez, DE Wazer - 2013 - books.google.com
Inside the Sixth Edition of this now-classic reference, you will discover encyclopedic
coverage of topics ranging from basic science to sophisticated computer-based radiation …
coverage of topics ranging from basic science to sophisticated computer-based radiation …
Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer
Context Attempts to determine the clinical significance of BRCA1/2 mutations in ovarian
cancer have produced conflicting results. Objective To determine the relationships between …
cancer have produced conflicting results. Objective To determine the relationships between …
Ovarian cancer
Ovarian carcinomas are a heterogeneous group of neoplasms and are traditionally
subclassified based on type and degree of differentiation. Although current clinical …
subclassified based on type and degree of differentiation. Although current clinical …
Ovarian cancer: epidemiology, biology, and prognostic factors
CH Holschneider, JS Berek - Seminars in surgical oncology, 2000 - Wiley Online Library
Ovarian cancer varies widely in frequency among different geographic regions and ethnic
groups, with a high incidence in Northern Europe and the United States, and a low …
groups, with a high incidence in Northern Europe and the United States, and a low …
Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin–cohort study in Ontario, Canada
Background: BRCA1 and BRCA2 mutations in general populations and in various types of
cancers have not been well characterized. We investigated the presence of these mutations …
cancers have not been well characterized. We investigated the presence of these mutations …
Identification of six new susceptibility loci for invasive epithelial ovarian cancer
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer
(EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 …
(EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 …