Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Genome mining of biosynthetic pathways with no identifiable core enzymes can lead to
discovery of the so-called unknown (biosynthetic route)–unknown (molecular structure) …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large
group of structurally diverse natural products. Their biological activities and unique …

Transfer RNAs (tRNA) are best known for their role as adaptors during translation of the
genetic code. Beyond their canonical role during protein biosynthesis, tRNAs also perform …

Lantibiotics are a class of peptide antibiotics that contain one or more thioether bonds. The
lantibiotic nisin is an antimicrobial peptide that is widely used as a food preservative to …

Natural products have played a prominent role in the history of organic chemistry, and they
continue to be important as drugs, biological probes, and targets of study for synthetic and …

Cyclic dipeptides, also know as diketopiperazines (DKP), the simplest cyclic forms of
peptides widespread in nature, are unsurpassed in their structural and bio-functional …

Covering: up to the end of February 2010 This review surveys the natural products
described from entomopathogenic Hypocrealean fungi, including their structures, biological …

Microorganisms and their hosts communicate with each other through an array of signals.
The plant hormone auxin (indole-3-acetic acid; IAA) is central in many aspects of plant …