The attachment of cells to the extracellular matrix (ECM) is the hallmark of structure–function
stability and well-being. ECM detachment in localized tumors precedes abnormal …

The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

Simple Summary Anoikis is a programmed cell death process resulting from the loss of
interaction between cells and the extracellular matrix. Therefore, it is necessary to overcome …

Field cancerization and metastasis are the leading causes for cancer recurrence and
mortality in cancer patients. The formation of primary, secondary tumors or metastasis is …

Excessive cellular oxidative stress is widely perceived as a key factor in pathophysiological
conditions and cancer development. Healthy cells use several mechanisms to maintain …

Pyruvate is irreversibly decarboxylated to acetyl coenzyme A by mitochondrial pyruvate
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …

Abstract Elevated levels of Reactive Oxygen Species (ROS), increased antioxidant ability
and the maintenance of redox homeostasis can cumulatively contribute to tumor progression …

The loss of cell-matrix interactions induces apoptosis, known as anoikis. For successful
distant metastasis, circulating tumor cells (CTCs) that have lost matrix attachment need to …

Flavonoids have been recently identified as a potential anticancer agent against various
human epithelial cancers. In this study, the elucidation of mechanisms underlying the …

The development of effective treatments for cancers requires investigations for a more
detailed and comprehensive understanding of the basic cellular mechanisms involved in …