Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

Malaria, a parasite vector-borne disease, is one of the most significant health threats in
tropical regions, despite the availability of individual chemoprophylaxis. Malaria …

Malaria is one of the most life-threatening infectious diseases and constitutes a major health
problem, especially in Africa. Although artemisinin combination therapies remain efficacious …

Introduction Cotrimoxazole (CTX) has been used for half a century. It is inexpensive hence
the reason for its almost universal availability and wide clinical spectrum of use. In the last …

We hypothesise that intraerythrocytic malaria parasite metabolism is not merely fulfilling the
need for ATP generation, but is evolved to support rapid proliferation, similar to that seen in …

Although the illness malaria is caused by the asexual blood stages, the presence of
gametocytes is directly responsible for the infection of the vector Anopheles, thus …

We have analyzed the activities of the antifolates pyrimethamine (PM), chlorcycloguanil
(CCG), WR99210, trimethoprim (TMP), methotrexate (MTX), and trimetrexate (TMX) against …

The treatment efficacy and effects of artemether-lumefantrine (AL) and amodiaquine-
sulfalenepyrimethamine (ASP) on gametocyte carriage were evaluated in 181 children 10 …

Objective To test the efficacy of sulfadoxine–pyremethamine (SP) monotherapy and
establish the prevalence of mutations in dhfr and dhps in Brazzaville, Congo. Method We …

Background Amodiaquine is frequently used as a partner drug in combination therapy or in
some setting as monotherapy, but little is known about its effects on gametocyte production …