Since the discovery of antimicrobial peptide responses 40 years ago, the fruit fly Drosophila
melanogaster has proven to be a powerful model for the study of innate immunity. Early work …

To combat infection, the fruit fly Drosophila melanogaster relies on multiple innate defense
reactions, many of which are shared with higher organisms. These reactions include the use …

Commensal microbes colonize the gut epithelia of virtually all animals and provide several
benefits to their hosts. Changes in commensal populations can lead to dysbiosis, which is …

Interactions between commensals and the host impact the metabolic and immune status of
metazoans. Their deregulation is associated with age-related pathologies like chronic …

Intestinal homeostasis is achieved, in part, by the integration of a complex set of
mechanisms that eliminate pathogens and tolerate the indigenous microbiota. Drosophila …

Although Drosophila systemic immunity is extensively studied, little is known about the fly's
intestine-specific responses to bacterial infection. Global gene expression analysis of …

Gut homeostasis is controlled by both immune and developmental mechanisms, and its
disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the …

Although commensalism with gut microbiota exists in all metazoans, the host factors that
maintain this homeostatic relationship remain largely unknown. We show that the intestinal …

A hallmark of the potent, multifaceted antimicrobial defence of Drosophila melanogaster is
the challenge-induced synthesis of several families of antimicrobial peptides by cells in the …

The bacteria in the fruitfly Drosophila melanogaster of different life stages was quantified by
454 pyrosequencing of 16S rRNA gene amplicons. The sequence reads were dominated by …