Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets

M Zhang, Q Liu, H Meng, H Duan, X Liu, J Wu… - Signal transduction and …, 2024 - nature.com
Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

Cardioprotective potential of vanillic acid

B Yalameha, HR Nejabati… - Clinical and Experimental …, 2023 - Wiley Online Library
Nowadays, cardiovascular diseases (CVDs) are a global threat to public health, accounting
for almost one‐third of all deaths worldwide. One of the key mechanistic pathways …

Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway

H Liu, T Zhang, WY Zhang, SR Huang, Y Hu… - Experimental …, 2023 - Elsevier
Background Ischemic stroke, a major cause of death and disability worldwide, results from
reduced blood flow to the brain, leading to irreversible neuronal damage. Recent evidence …

Therapeutic potential of hydrogen sulfide in ischemia and reperfusion injury

X Sun, S Wu, C Mao, Y Qu, Z Xu, Y Xie, D Jiang… - Biomolecules, 2024 - mdpi.com
Ischemia–reperfusion (I/R) injury, a prevalent pathological condition in medical practice,
presents significant treatment challenges. Hydrogen sulfide (H2S), acknowledged as the …

The effect of rutin on ovarian ischemia-reperfusion injury in a rat model

C Nayki, U Nayki, F Keskin Cimen… - Gynecological …, 2018 - Taylor & Francis
The effect of rutin on ovarian ischemia-reperfusion (I/R) injury was investigated in this
experimental study. Eighteen Wistar albino female rats were divided into three groups as …

The Effect of Taxifolin on Cisplatin‐Induced Pulmonary Damage in Rats: A Biochemical and Histopathological Evaluation

E Unver, M Tosun, H Olmez, M Kuzucu… - Mediators of …, 2019 - Wiley Online Library
The effect of taxifolin on cisplatin‐induced oxidative pulmonary damage was investigated
biochemically and histopathologically in male albino Wistar rats. There were four groups …

Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury

R Kongsui, S Surapinit, T Promsrisuk… - Brazilian Journal of …, 2023 - SciELO Brasil
Oxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The
accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) …

Dietary protective potential of fucoxanthin as an active food component on neurological disorders

Y Chen, H Lu, Y Ding, S Liu, Y Ding, B Lu… - Journal of Agricultural …, 2023 - ACS Publications
The prevalence of neurodegenerative, cerebrovascular, and psychiatric diseases and other
neurological disorders has increased dramatically worldwide. Fucoxanthin is an algal …

Tetrahydropalmatine promotes random skin flap survival in rats via the PI3K/AKT signaling pathway

J Yang, J Deng, K Wang, A Wang, G Chen… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Flap necrosis is the most common complication after flap
transplantation, but its prevention remains challenging. Tetrahydropalmatine (THP) is the …

Sevoflurane protects the liver from ischemia-reperfusion injury by regulating Nrf2/HO-1 pathway

H Ma, B Yang, L Yu, Y Gao, X Ye, Y Liu, Z Li… - European Journal of …, 2021 - Elsevier
We aimed to investigate the role and mechanism of sevoflurane (SEV) preconditioning in
liver ischemia-reperfusion (I/R) injury. In vivo, rats were randomly divided into Sham group …