Natural products (NPs) are important sources of clinical drugs due to their structural diversity
and biological prevalidation. However, the structural complexity of NPs leads to synthetic …

Over the course of the past half century, the structural elucidation of unknown natural
products has undergone a tremendous revolution. Before World War II, a chemist would …

During the past 25 years, marinenatural products chemists have enjoyed unrivaled success
in the discovery of unique, new compounds. History has now proven that marine organisms …

The synthetic utility and potential power of the Diels–Alder (D–A) reaction in organic
chemistry is evident. These significances have been extended to the synthesis of a plethora …

Microbial symbionts are often a source of chemical novelty and can contribute to host
defense against antagonists. However, the ecological relevance of chemical mediators …

The marine environment is a seemingly inexhaustible treasury of organisms whose
secondary metabolites bear witness to the lavishness and inventiveness with which nature …

Marine natural products, the secondary or nonprimary metabolites produced by organisms
that live in the sea, have received increasing attention from chemists and pharmacologists …

The isolation and structures of two new cyclic hexapeptides and two new macrocyclic ethers
from the aplousobranch ascidian Lissoclinumbistratum are described. Their structures were …

Microorganisms from the order Burkholderiales have been the source of a number of
important classes of natural products in recent years. For example, study of the beetle …

We have developed an efficient and highly stereocontrolled synthesis of bistramide A, a
selective activator of protein kinase C isotype δ. Our synthetic strategy featured a novel …