Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …

The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …

Background Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic
state that places them at a dramatically increased lethal risk. Although platelet activation is …

The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing global pandemic has presented a health emergency of unprecedented …

There is an urgent need to understand the pathogenesis of coronavirus disease 2019
(COVID-19). In particular, thrombotic complications in patients with COVID-19 are common …

Rationale: Coronavirus disease 2019 (COVID-19) is characterized by increased incidence
of microthrombosis with hyperactive platelets sporadically containing viral RNA. It is unclear …

Rationale: In addition to the overwhelming lung inflammation that prevails in coronavirus
disease 2019 (COVID-19), hypercoagulation and thrombosis contribute to the lethality of …

The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Platelets, non-nucleated blood components first described over 130 years ago, are
recognized as the primary cell regulating hemostasis and thrombosis. The vascular …

Platelets are the primary cellular mediators of hemostasis and this function firmly acquaints
them with a variety of inflammatory processes. For example, platelets can act as circulating …