Propagation of uncertainty in the mechanical and biological response of growing tissues using multi-fidelity Gaussian process regression

T Lee, I Bilionis, AB Tepole - Computer methods in applied mechanics and …, 2020 - Elsevier
A key feature of living tissues is their capacity to remodel and grow in response to
environmental cues. Within continuum mechanics, this process can be captured with the …

A biphasic multilayer computational model of human skin

D Sachs, A Wahlsten, S Kozerke, G Restivo… - … and modeling in …, 2021 - Springer
The present study investigates the layer-specific mechanical behavior of human skin.
Motivated by skin's histology, a biphasic model is proposed which differentiates between …

A novel ultra-light suction device for mechanical characterization of skin

B Müller, J Elrod, M Pensalfini, R Hopf, O Distler… - PloS one, 2018 - journals.plos.org
Suction experiments have been extensively applied for skin characterization. In these tests
the deformation behavior of superficial tissue layers determines the elevation of the skin …

Predicting the effect of aging and defect size on the stress profiles of skin from advancement, rotation and transposition flap surgeries

T Lee, AK Gosain, I Bilionis, AB Tepole - … of the Mechanics and Physics of …, 2019 - Elsevier
Predicting mechanical stress contours on skin resulting from local tissue rearrangement
surgeries is needed to design optimal treatment plans and avoid wound healing …

Improving reconstructive surgery design using Gaussian process surrogates to capture material behavior uncertainty

C Stowers, T Lee, I Bilionis, AK Gosain… - Journal of the mechanical …, 2021 - Elsevier
To produce functional, aesthetically natural results, reconstructive surgeries must be
planned to minimize stress as excessive loads near wounds have been shown to produce …

On the optimal choice of a hyperelastic model of ruptured and unruptured cerebral aneurysm

DV Parshin, AI Lipovka, AS Yunoshev… - Scientific Reports, 2019 - nature.com
In the last decade, preoperative modelling of the treatment of cerebral aneurysms is being
actively developed. Fluid-structure interaction problem is a key point of a such modelling …

On the reliability of suction measurements for skin characterization

B Mueller, J Elrod, O Distler… - Journal of …, 2021 - asmedigitalcollection.asme.org
Abstract in vivo skin characterization methods were shown to be useful in the detection of
microstructural alterations of the dermis due to skin diseases. Specifically, the diagnostic …

Bilayer stiffness identification of soft tissues by suction

N Connesson, N Briot, PY Rohan, PA Barraud… - Experimental …, 2023 - Springer
Background In vivo mechanical characterisation of biological soft tissue is challenging, even
under moderate quasi-static loading. Clinical application of suction-based methods is …

[HTML][HTML] In vivo stress relaxation of human scalp

W Lear, CM Blattner, TA Mustoe, JJ Kruzic - Journal of the Mechanical …, 2019 - Elsevier
Objective Conduct a first in vivo study on the large deformation stress relaxation behavior of
the human scalp. Methods This study was conducted during Mohs micrographic surgery of …

Bayesian inference with gaussian process surrogates to characterize anisotropic mechanical properties of skin from suction tests

G Song, J An, AB Tepole, T Lee - Journal of …, 2022 - asmedigitalcollection.asme.org
One of the intrinsic features of skin and other biological tissues is the high variation in the
mechanical properties across individuals and different demographics. Mechanical …