Transforming growth factor beta (TGFβ) signalling is essential for wound healing, including
both non-specific scar formation and tissue-specific regeneration. Specific TGFβ isoforms …

This review explores the historical and current state of our knowledge about urodele limb
regeneration. Topics discussed are (1) blastema formation by the proteolytic histolysis of …

The failure to replace damaged body parts in adult mammals results from a muted growth
response and fibrotic scarring. Although infiltrating immune cells play a major role in …

Background Wound healing is the first stage of a series of cellular events that are necessary
to initiate a regenerative response. Defective wound healing can block regeneration even in …

The salamander has the remarkable ability to regenerate its limb after amputation. Cells at
the site of amputation form a blastema and then proliferate and differentiate to regrow the …

Humans and other mammals are limited in their natural abilities to regenerate lost body
parts. By contrast, many salamanders are highly regenerative and can spontaneously …

Understanding how the limb blastema is established after the initial wound healing
response is an important aspect of regeneration research. Here we performed parallel …

Among tetrapods, only urodele salamanders, such as the axolotl Ambystoma mexicanum,
can completely regenerate limbs as adults. The mystery of why salamanders, but not other …

After amputation, axolotl salamanders can regenerate their limbs, but the degree to which
limb regeneration recapitulates limb development remains unclear. One limitation in …

Regeneration of missing body parts is an incredible ability which is present in a wide
number of species. However, this regenerative capability varies among different organisms …