Clinical metagenomic next-generation sequencing (mNGS), the comprehensive analysis of
microbial and host genetic material (DNA and RNA) in samples from patients, is rapidly …

Agnostic metagenomic next-generation sequencing (mNGS) has emerged as a promising
single, universal pathogen detection method for infectious disease diagnostics. This …

Background Metagenomic next-generation sequencing (NGS) of cerebrospinal fluid (CSF)
has the potential to identify a broad range of pathogens in a single test. Methods In a 1-year …

Thousands of pathogens are known to infect humans, but only a fraction are readily
identifiable using current diagnostic methods. Microbial cell-free DNA sequencing offers the …

Metagenomic next-generation sequencing (mNGS) for pan-pathogen detection has been
successfully tested in proof-of-concept case studies in patients with acute illness of unknown …

Respiratory syncytial virus (RSV) infection is a significant cause of hospitalization of children
in North America and one of the leading causes of death of infants less than 1 year of age …

We report unbiased metagenomic detection of chikungunya virus (CHIKV), Ebola virus
(EBOV), and hepatitis C virus (HCV) from four human blood samples by MinION nanopore …

The advent of next-generation sequencing (NGS) technologies has expanded our ability to
detect and analyze microbial genomes and has yielded novel molecular approaches for …

Whole-genome sequencing (WGS) of pathogens is becoming increasingly important not
only for basic research but also for clinical science and practice. In virology, WGS is …

Importance Identifying infectious causes of subacute or chronic meningitis can be
challenging. Enhanced, unbiased diagnostic approaches are needed. Objective To present …