Cytokine storm in COVID-19: immunopathogenesis and therapy

C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
A cytokine storm is a hyperinflammatory state secondary to the excessive production of
cytokines by a deregulated immune system. It manifests clinically as an influenza-like …

The neurobiology of SARS-CoV-2 infection

J Meinhardt, S Streit, C Dittmayer, RV Manitius… - Nature Reviews …, 2024 - nature.com
Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated
55–60% of those infected developing COVID-19. Since the beginning of the pandemic in …

APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical …

SN Kurki, J Kantonen, K Kaivola, L Hokkanen… - Acta neuropathologica …, 2021 - Springer
Apolipoprotein E ε4 allele (APOE4) has been shown to associate with increased
susceptibility to SARS-CoV-2 infection and COVID-19 mortality in some previous genetic …

SARS-CoV-2 causes lung infection without severe disease in human ACE2 knock-in mice

ES Winkler, RE Chen, F Alam, S Yildiz, JB Case… - Journal of …, 2022 - Am Soc Microbiol
The development of mouse models for coronavirus disease 2019 (COVID-19) has enabled
testing of vaccines and therapeutics and defining aspects of severe acute respiratory …

Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players …

P Frisoni, M Neri, S D'Errico, L Alfieri… - … Science, Medicine and …, 2022 - Springer
This study involves the histological analysis of samples taken during autopsies in cases of
COVID-19 related death to evaluate the inflammatory cytokine response and the tissue …

Hippocampal subfield abnormalities and biomarkers of pathologic brain changes: from SARS-CoV-2 acute infection to post-COVID syndrome

M Díez-Cirarda, M Yus-Fuertes, R Sanchez-Sanchez… - …, 2023 - thelancet.com
Background Cognitive deficits are among the main disabling symptoms in COVID-19
patients and post-COVID syndrome (PCS). Within brain regions, the hippocampus, a key …

[HTML][HTML] SARS-CoV-2 infection and multi-organ system damage: A review

AA Rabaan, S Smajlović, H Tombuloglu… - Biomolecules and …, 2023 - ncbi.nlm.nih.gov
The SARS-CoV-2 infection causes COVID-19, which has affected approximately six hundred
million people globally as of 8 2022. Organs and cells harboring angiotensin-converting …

Myocardial pathology in COVID-19-associated cardiac injury: a systematic review

A Maiese, P Frati, F Del Duca, P Santoro, AC Manetti… - Diagnostics, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19) can potentially affect all organs owing to the
ubiquitous diffusion of the angiotensin-converting enzyme II (ACE2) receptor-binding …

Intranasal corticosteroid treatment on recovery of long‐term olfactory dysfunction due to COVID‐19

M Hosseinpoor, M Kabiri, M Rajati Haghi… - The …, 2022 - Wiley Online Library
Background and Aims Olfactory dysfunction is a recognized manifestation in patients
infected with Coronavirus Disease 2019 (COVID‐19). This investigation aimed to assess the …

SARS-Cov-2 infection and neuropathological findings: a report of 18 cases and review of the literature

L Lebrun, L Absil, M Remmelink… - Acta neuropathologica …, 2023 - Springer
Introduction COVID-19-infected patients harbour neurological symptoms such as stroke and
anosmia, leading to the hypothesis that there is direct invasion of the central nervous system …