Mammalian antimicrobial proteins and peptides: overview on the RNase A superfamily members involved in innate host defence
E Boix, MV Nogués - Molecular Biosystems, 2007 - pubs.rsc.org
The review starts with a general outlook of the main mechanisms of action of antimicrobial
proteins and peptides, with the final aim of understanding the biological function of …
proteins and peptides, with the final aim of understanding the biological function of …
Using NMR spectroscopy to elucidate the role of molecular motions in enzyme function
GP Lisi, JP Loria - Progress in nuclear magnetic resonance spectroscopy, 2016 - Elsevier
Conformational motions play an essential role in enzyme function, often facilitating the
formation of enzyme-substrate complexes and/or product release. Although considerable …
formation of enzyme-substrate complexes and/or product release. Although considerable …
Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram‐negative and Gram‐positive bacterial cell wall
M Torrent, M Badia, M Moussaoui, D Sanchez… - The FEBS …, 2010 - Wiley Online Library
The eosinophil cationic protein/RNase 3 and the skin‐derived RNase 7 are two human
antimicrobial RNases involved in host innate immunity. Both belong to the RNase A …
antimicrobial RNases involved in host innate immunity. Both belong to the RNase A …
The flexibility of a distant loop modulates active site motion and product release in ribonuclease A
The role of the flexible loop 1 in protein conformational motion and in the dissociation of
enzymatic product from ribonuclease A (RNase A) was investigated by creation of a chimeric …
enzymatic product from ribonuclease A (RNase A) was investigated by creation of a chimeric …
Both aromatic and cationic residues contribute to the membrane-lytic and bactericidal activity of eosinophil cationic protein
E Carreras, E Boix, HF Rosenberg, CM Cuchillo… - Biochemistry, 2003 - ACS Publications
Eosinophil cationic protein (ECP) and eosinophil derived neurotoxin (EDN) are proteins of
the ribonuclease A (RNase A) superfamily that have developed biological properties related …
the ribonuclease A (RNase A) superfamily that have developed biological properties related …
Antimicrobial action and cell agglutination by the eosinophil cationic protein are modulated by the cell wall lipopolysaccharide structure
D Pulido, M Moussaoui, D Andreu… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Antimicrobial proteins and peptides (AMPs) are essential effectors of innate immunity, acting
as a first line of defense against bacterial infections. Many AMPs exhibit high affinity for cell …
as a first line of defense against bacterial infections. Many AMPs exhibit high affinity for cell …
Eosinophil major basic protein: first identified natural heparanase-inhibiting protein
V Temkin, H Aingorn, I Puxeddu, O Goldshmidt… - Journal of allergy and …, 2004 - Elsevier
BACKGROUND: Heparanase and eosinophils are involved in several diseases, including
inflammation, cancer, and angiogenesis. OBJECTIVE: We sought to determine whether …
inflammation, cancer, and angiogenesis. OBJECTIVE: We sought to determine whether …
Functional magnetic nanoparticles–assisted electrochemical biosensor for eosinophil cationic protein in cell culture
CY Lee, LP Wu, TT Chou, YZ Hsieh - Sensors and Actuators B: Chemical, 2018 - Elsevier
A low-cost electrochemical biosensor, assisted by a new type of functional magnetic
nanoparticles (NPs), has been developed to detect eosinophil cationic protein (ECP), a …
nanoparticles (NPs), has been developed to detect eosinophil cationic protein (ECP), a …
The antipathogen activities of eosinophil cationic protein
The eosinophil cationic protein (ECP) is a secretory ribonuclease, which is found in the
eosinophilic leukocyte and involved in the innate immune system. Its cytotoxic activity is …
eosinophilic leukocyte and involved in the innate immune system. Its cytotoxic activity is …
Topography studies on the membrane interaction mechanism of the eosinophil cationic protein
The eosinophil cationic protein (ECP) is an antipathogen protein involved in the host
defense system. ECP displays bactericidal and membrane lytic capacities [Carreras et …
defense system. ECP displays bactericidal and membrane lytic capacities [Carreras et …