Ferritin, an iron-storage protein, regulates cellular iron metabolism and oxidative stress. The
ferritin structure is characterized as a spherical cage, inside which large amounts of iron are …

The encapsulation of anticancer metal-based drugs within a protein nanocage represents a
valuable strategy to improve the efficacy and selectivity of these compounds towards cancer …

Ferritin may serve as a nanocarrier for the selective delivery of anticancer metallodrugs.
Here, we have prepared and characterized a well-defined conjugate between the gold drug …

Herein, we report on the successful encapsulation into human H-ferritin of two highly
charged Ru (II) polypyridyl complexes,[Ru (phen) 2L′] 2+(Ru1, with L′= 4, 4′-(2, 5, 8, 11 …

The altered regulation of iron uptake and metabolism in cancerous cells, along with the
potential of this metal to cause oxidative stress and cell death, makes iron overload an …

The development of multidrug resistance (MDR) is the primary contributor to the failure of
cancer treatment, ultimately leading to tumor recurrence and metastasis. Ferroptosis, an iron …

Human cytoplasmic ferritins are heteropolymers of H and L subunits containing a catalytic
ferroxidase center and a nucleation site for iron biomineralization, respectively. Here, ESI …

Ferroptosis is a newly detected iron-dependent form of regulated cell death. Sono-
photodynamic therapy (SPDT) can generate reactive oxygen species (ROS) and induce cell …

Transferrin is a protein involved in iron uptake by cells and has been identified as a potential
target for directing drug-loaded nanoparticles for cancer treatment and diagnosis. Most …

The search for high relaxivities and increased specificity continues to be central to the
development of paramagnetic contrast agents for magnetic resonance imaging (MRI) …