Background P53 is the most widely investigated molecular marker in bladder cancer. We
aimed to review comprehensively the evidence for use of changes in P53 to predict bladder …

PURPOSE: An extensive body of literature regarding p53 has accumulated during the last 2
decades. The cellular mechanisms of p53 are complex yet well-defined, whereas its clinical …

Radical radiotherapy and surgery achieve similar cure rates in muscle-invasive bladder
cancer, but the choice of which treatment would be most beneficial cannot currently be …

Standard treatment for muscle-invasive bladder cancer is cystectomy. Trimodality treatment,
including transurethral resection of the bladder tumor (TURBT), radiation therapy and …

Objectives: Anomalies of the p53 tumor suppressor gene have been reported for a variety of
different tumor types. Also in urothelial cancer accumulation of the P53 protein has been …

Purpose: Several groups have reported the value of bladder preservation by a combined
treatment protocol, including transurethral resection (TUR-B) and radiochemotherapy (RCT) …

OBJECTIVE: For nearly 20 years, the putative prognostic value of P53
immunohistochemistry in bladder cancer has been controversially discussed, and key …

Background and purpose: In a recent study on patients with transitional cell cancer of the
bladder treated with curative radiotherapy following TUR-T, we demonstrated that a low …

In the present review, we have evaluated the outcome of radiotherapy in patients with
bladder cancer. The exact value of radical radiotherapy is difficult to establish because …

The retinoblastoma tumour suppressor protein (Rb) has come a long way since its initial
discovery in 1986. Encoded by the first candidate tumour suppressor gene it has emerged a …