Alzheimer's disease and its treatment by different approaches: A review

S Srivastava, R Ahmad, SK Khare - European Journal of Medicinal …, 2021 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mental ability
development and interrupts neurocognitive function. This neuropathological condition is …

The pharmacological action of kaempferol in central nervous system diseases: a review

J Silva dos Santos, JP Goncalves Cirino… - Frontiers in …, 2021 - frontiersin.org
Kaempferol (KPF) is a flavonoid antioxidant found in fruits and vegetables. Many studies
have described the beneficial effects of dietary KPF in reducing the risk of chronic diseases …

Updates in Alzheimer's disease: from basic research to diagnosis and therapies

E Liu, Y Zhang, JZ Wang - Translational Neurodegeneration, 2024 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized
pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and …

[HTML][HTML] Amyloid cascade hypothesis for the treatment of alzheimer's disease: progress and challenges

T Wu, D Lin, Y Cheng, S Jiang, MW Riaz, N Fu… - Aging and …, 2022 - ncbi.nlm.nih.gov
The amyloid cascade hypothesis has always been a research focus in the therapeutic field
of Alzheimer's disease (AD) since it was put forward. Numerous researchers attempted to …

Link between diabetes and Alzheimer's disease due to the shared amyloid aggregation and deposition involving both neurodegenerative changes and neurovascular …

GD Stanciu, V Bild, DC Ababei, RN Rusu… - Journal of Clinical …, 2020 - mdpi.com
Diabetes and Alzheimer's disease are two highly prevalent diseases among the aging
population and have become major public health concerns in the 21st century, with a …

Pivotal role of nitrogen heterocycles in Alzheimer's disease drug discovery

S Kumari, K Maddeboina, RD Bachu, SHS Boddu… - Drug Discovery …, 2022 - Elsevier
Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively
worsens with time. Clinical options are limited and only provide symptomatic relief to AD …

The Role of Intracellular Ca2+ and Mitochondrial ROS in Small Aβ1-42 Oligomer-Induced Microglial Death

A Jekabsone, S Jankeviciute, K Pampuscenko… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia worldwide, and it contributes
up to 70% of cases. AD pathology involves abnormal amyloid beta (Aβ) accumulation, and …

Disturb mitochondrial associated proteostasis: Neurodegeneration and imperfect ageing

YA Jagtap, P Kumar, S Kinger, AR Dubey… - Frontiers in Cell and …, 2023 - frontiersin.org
The disturbance in mitochondrial functions and homeostasis are the major features of
neuron degenerative conditions, like Parkinson's disease, Amyotrophic Lateral Sclerosis …

Pharmacotherapy of Alzheimer's disease: Seeking clarity in a time of uncertainty

N Husna Ibrahim, MF Yahaya, W Mohamed… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is recognized as a major health hazard that mostly affects people
older than 60 years. AD is one of the biggest medical, economic, and social concerns to …

Targeting mitochondrial dysfunction in neurodegenerative diseases: expanding the therapeutic approaches by plant-derived natural products

X Zhang, L Wang, B Li, J Shi, J Xu, M Yuan - Pharmaceuticals, 2023 - mdpi.com
Mitochondria are the primary source of energy production in neurons, supporting the high
energy consumption of the nervous system. Inefficient and dysfunctional mitochondria in the …