Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

The development of drug resistance is one of the main causes of failure in anti-cancer
treatments. Tumor cells adopt many strategies to counteract the action of chemotherapeutic …

Voltage dependent anion channel 2 (VDAC2) is an outer mitochondrial membrane porin
known to play a significant role in apoptosis and calcium signaling. Abnormalities in calcium …

The present review focusses on the regulation and interplay of cardiac SR Ca2+ handling
proteins involved in SR Ca2+ uptake and release, ie, SERCa2/PLN and RyR2. Both RyR2 …

Background: A loss-of-function cardiac ryanodine receptor (RyR2) mutation, I4855M+/–, has
recently been linked to a new cardiac disorder termed RyR2 Ca2+ release deficiency …

The epidermal growth factor receptor (EGFR) is one of the main tumor drivers and is an
important therapeutic target for many cancers. Calcium is important in EGFR signaling …

Hypertrophic cardiomyopathy (HCM) is triggered mainly by mutations in genes encoding
sarcomeric proteins, but a significant proportion of patients lack a genetic diagnosis. We …

To discover new multifunctional agents for the treatment of cardiovascular diseases, we
designed and synthesized a series of compounds with a cyclopropyl alcohol moiety and …

Simple Summary Sorcin is a protein that helps cells handle calcium. It is often found in high
amounts in cancer cells, especially those that are resistant to treatment. Sorcin plays a key …

BACKGROUND: Ca2+ mishandling in cardiac Purkinje cells is a well-known cause of
cardiac arrhythmias. The Purkinje cell resident inositol 1, 4, 5-trisphosphate receptor 1 …