Sliding clamps play a pivotal role in the process of replication by increasing the processivity
of the replicative polymerase. They also serve as an interacting platform for a plethora of …

The proper initiation and occurrence of DNA synthesis depends on the formation and
rearrangements of nucleoprotein complexes within the origin of DNA replication. In this …

Despite the WHO's recommended treatment regimen, challenges such as patient non-
adherence and the emergence of drug-resistant strains persist with TB claiming 1.5 million …

DNA replication is fundamental for life, yet a detailed understanding of bacterial DNA
replication is limited outside the organisms Escherichia coli and Bacillus subtilis. Many …

Abstract Mycobacterium tuberculosis Nei2 (Rv3297) is a BER glycosylase that removes
oxidized base lesions from ssDNA and replication fork‐mimicking substrates. We show that …

Helicobacter pylori, a gram-negative and microaerophilic bacterium, is the major cause of
chronic gastritis, gastric ulcers and gastric cancer. Owing to its central role, DNA replication …

Abstract DNA polymerase III (DNA pol III) is a multi-subunit replication machine responsible
for the accurate and rapid replication of bacterial genomes, however, how it functions in …

Tuberculosis, caused by Mycobacterium tuberculosis, is one of the most common causes of
death in the world. Mycobacterium tuberculosis-sliding clamp is a protein essential for many …

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infection is a serious threat
to human health. γδT cells, which are characterized by major histocompatibility complex …

DNA replication introduces thousands of RNA primers into the lagging strand that need to be
removed for replication to be completed. In Escherichia coli when the replicative DNA …