Background: Limb muscle dysfunction is prevalent in chronic obstructive pulmonary disease
(COPD) and it has important clinical implications, such as reduced exercise tolerance …

In evolutionary terms, GH and intracellular STAT 5 signaling is a very old regulatory system.
Whereas insulin dominates periprandially, GH may be viewed as the primary anabolic …

A. Genetic, molecular, and transgenic models B. Human GH rhythms III. Neuropeptide
Regulation of the GH Axis: Somatostatin and GHRH

Increased life expectancy combined with the aging baby boomer generation has resulted in
an unprecedented global expansion of the elderly population. The growing population of …

There is a wide variety of kinds of lipids, and complex structures which determine the
diversity and complexity of their functions. With the basic characteristic of water insolubility …

The widespread increase in life expectancy is accompanied by an increased prevalence of
features of physical frailty. Signs and symptoms may include sarcopenia and osteopenia …

The secretion of growth hormone (GH) is regulated through a complex neuroendocrine
control system, especially by the functional interplay of two hypothalamic hypophysiotropic …

Mean plasma GH concentrations are controlled by the frequency, amplitude, and duration of
underlying GH secretory bursts as well as by the half-life of endogenous GH. We …

Body composition exhibits marked variations across the early human lifetime. The precise
physiological mechanisms that drive such developmental adaptations are difficult to …

In humans, growth hormone (GH) is secreted from the anterior pituitary in a pulsatile pattern.
The traditional view is that this secretory pattern is driven by two counter regulatory …