Despite great advances in the development of modern anticancer drugs, it is still challenging
to find safer and more effective ones due to a new spectrum of diseases and emerging drug …

The proline-rich Akt substrate of 40 kDa (PRAS40) acts at the intersection of the Akt-and
mammalian target of rapamycin (mTOR)-mediated signaling pathways. The protein kinase …

Radioresistance is a major cause of decreasing the efficiency of radiotherapy for non-small
cell lung cancer (NSCLC). To understand the radioresistance mechanisms in NSCLC, we …

Introduction: Inhibition of protein kinases has become a standard of modern clinical
oncology. PIM1 belongs to a novel class of serine/threonine kinases with distinct molecular …

The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of
serine/threonine kinases that regulates numerous signaling networks that promote cell …

Background—The mechanistic target of rapamycin (mTOR) comprises 2 structurally distinct
multiprotein complexes, mTOR complexes 1 and 2 (mTORC1 and mTORC2). Deregulation …

Abstract The p21-activated Ser/Thr kinase 1 (PAK1) kinase has an essential role in
tumorigenesis and cell survival in many cancers, but its regulation is not fully understood. In …

Radioresistance hinders the therapeutic outcomes of radiotherapy in non‑small cell lung
cancer (NSCLC). Although long non‑coding RNAs (lncRNAs) have been demonstrated to …

Background: PIM1 kinase is coexpressed with c-MYC in human prostate cancers (PCs) and
dramatically enhances c-MYC-induced tumorigenicity. Here we examine the effects of a …

Radioresistance has been an important factor in restricting efficacy of radiotherapy for non-
small cell lung cancer (NSCLC) patients and new approaches to inhibit cancer growth and …