Translational research on endogenous gaseous mediators—nitric oxide, carbon monoxide,
and hydrogen sulfide—has exploded over the past decade. Drugs that modulate either the …

BACKGROUND: Eosinophilic airway inflammation is heterogeneous in asthmatic patients.
We recently described a distinct subtype of asthma defined by the expression of genes …

Asthma is often described as an inflammatory disease of the lungs and in most patients
symptomatic treatment with bronchodilators or inhaled corticosteroids is sufficient to control …

Introduction Asthma is a variable lung condition whereby patients experience periods of
controlled and uncontrolled asthma symptoms. Patients who experience prolonged periods …

Background Aiming at partly controlled asthma (PCa) instead of controlled asthma (Ca)
might decrease asthma medication use. Biomarkers, such as the fraction of exhaled nitric …

Background and aims Although increasing evidence suggests involvement of the distal
airway in all stages of asthma, it is not known whether structural changes (defined as airway …

Measurement of eosinophilic airway inflammation can assist in the diagnosis of allergic
asthma and in the management of exacerbations, however its clinical implementation …

BACKGROUND: Fractional exhaled nitric oxide (FENO) has been implicated as a pulmonary
biomarker. The aim of this study was to compare the performance of a new hand-held device …

Exhaled nitric oxide (eNO) has been proposed as a noninvasive marker of airway
inflammation in asthma. In asthmatic patients, exhaled NO levels have been shown to relate …

The aim of the current study was to determine the impact and interaction of important
influencing factors on the fraction of exhaled nitric oxide (FeNO). FeNO was measured in a …