Nitric oxide (NO) is involved in many physiological processes and several lines of evidence
have indicated that NO plays a complex and diverse role in the modulation of pain. Nitric …

Purified from the roots of the plant Sinomenium acutum, sinomenine is traditionally used in
China and Japan for treating rheumatism and arthritis. Previously, we have demonstrated …

Abnormal neuronal activity in sensory ganglia contributes to chronic pain. There is evidence
that signals can spread between cells in these ganglia, which may contribute to this activity …

Background: The neural mobilization technique is a noninvasive method that has proved
clinically effective in reducing pain sensitivity and consequently in improving quality of life …

Neuropathic pain is a debilitating form of treatment resistant chronic pain and responds
poorly to the clinically available therapies. Studies from animal models of neuropathic pain …

Background Reactive oxygen species (ROS) induced oxidative stress is linked to numerous
neurological diseases, including neuropathic pain. Natural ROS scavenging enzymes like …

During inflammation, chemokines play a central role by mediating the activation of
inflammatory cascade responses in tissue injury. Among more than 200 chemokines …

Objectives: Evidences of oxidative and/or nitrosative stress in type 2 diabetes mellitus were
demonstrated in experimental and human studies. This study is aimed to assess the serum …

Leptin is an adipocytokine that is primarily secreted by white adipose tissue, and it
contributes to the pathogenesis of neuropathic pain in collaboration with N-methyl-D …

Monosodium glutamate (MSG) is a widely used food additive. Although it is generally
considered safe, some questions regarding the impact of its use on general health have …