Abstract Computational Fluid Dynamics (CFD) is a valuable tool for studying fluid
environments within cell culture bioreactors and optimizing processing parameters, but it …

Optimizing bioprocesses requires an in-depth understanding, from a bioengineering
perspective, of the cultivation systems used. A bioengineering characterization is typically …

The multi-parameter intricate process control of bioreactor systems poses an urgent
challenge to cell culture. It is feasible to simulate and analyze the implications of each …

The rising quantity and quality demands in biopharmaceutical manufacturing require a deep
understanding of the underlying bioprocesses. For this purpose, computational fluid …

A novel single‐use bioreactor was recently introduced to the market that is agitated by
impellers suspended on flexible ropes rather than a rigid shaft. Computational fluid …

Two-way Euler-Lagrange simulations are performed to characterize the hydrodynamics in
the single-use bioreactor Mobius® CellReady 3 L. The hydrodynamics in stirred tank …

Understanding the hydrodynamic conditions in bioreactors is of utmost importance for the
selection of operating conditions during cell culture process development. In the present …

A strategy based on the Reynolds averaged two-fluid model is proved to be effective for the
simulation of a turbulent gas-liquid stirred tank in the whole range of possible flow regimes …

Cell culture scale‐up is a challenging task due to the simultaneous change of multiple
hydrodynamic process characteristics and their different dependencies on the bioreactor …

The perfect mixing process ensures the ideal substrate conditions for microorganisms to live
to produce ethanol in the fermenter. The critical factors that affect the mixing process are the …