Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host

T Belcher, V Dubois, A Rivera-Millot, C Locht… - Virulence, 2021 - Taylor & Francis
The highly contagious whooping cough agent Bordetella pertussis has evolved as a human-
restricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and …

Bordetella Type III Secretion Injectosome and Effector Proteins

J Kamanova - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Pertussis, also known as whooping cough, is a resurging acute respiratory disease of
humans primarily caused by the Gram-negative coccobacilli Bordetella pertussis, and less …

Bordetella bronchiseptica and Bordetella pertussis: similarities and differences in infection, immuno-modulation, and vaccine considerations

B Miguelena Chamorro, K De Luca… - Clinical Microbiology …, 2023 - Am Soc Microbiol
Bordetella pertussis and Bordetella bronchiseptica belong to the genus Bordetella, which
comprises 14 other species. B. pertussis is responsible for whooping cough in humans, a …

Deciphering the antigen specificities of antibodies by clustering their complementarity determining region sequences

DS Saputri, HS Ismanto, DK Nugraha, Z Xu… - Msystems, 2023 - Am Soc Microbiol
Recent advances in adaptive immune receptor repertoire sequencing have provided
abundant B cell receptor (BCR) sequences under various conditions, including vaccination …

Genome wide CRISPR screen for Pasteurella multocida toxin (PMT) binding proteins reveals LDL Receptor Related Protein 1 (LRP1) as crucial cellular receptor

J Schoellkopf, T Mueller, L Hippchen, T Mueller… - PLoS …, 2022 - journals.plos.org
PMT is a protein toxin produced by Pasteurella multocida serotypes A and D. As causative
agent of atrophic rhinitis in swine, it leads to rapid degradation of the nasal turbinate bone …

[HTML][HTML] The application of genome-wide CRISPR-Cas9 screens to dissect the molecular mechanisms of toxins

B Wang, JZ Chen, XQ Luo, GH Wan, YL Tang… - Computational and …, 2022 - Elsevier
Many toxins are life-threatening to both animals and humans. However, specific antidotes
are not available for most of those toxins. The molecular mechanisms underlying the …

Some Examples of Bacterial Toxins as Tools

G Schmidt - Toxins, 2024 - mdpi.com
Pathogenic bacteria produce diverse protein toxins to disturb the host's defenses. This
includes the opening of epithelial barriers to establish bacterial growth in deeper tissues of …

Development of a targeted nanoLC-MS/MS method for quantitation of residual toxins from Bordetella pertussis

L Szymkowicz, DJ Wilson, DA James - Journal of Pharmaceutical and …, 2020 - Elsevier
Whooping cough is a highly contagious respiratory disease caused by Bordetella pertussis
(B. pertussis) infection. Pertussis pathogenesis is driven by cell-surface adhesion proteins …

Enzymatic Specificity of Conserved Rho GTPase Deamidases Promotes Invasion of Vibrio parahaemolyticus at the Expense of Infection

AE Lafrance, S Chimalapati, N Garcia Rodriguez… - Mbio, 2022 - Am Soc Microbiol
Vibrio parahaemolyticus is among the leading causes of bacterial seafood-borne acute
gastroenteritis. Like many intracellular pathogens, V. parahaemolyticus invades host cells …

Omics Analysis of Blood-Responsive Regulon in Bordetella pertussis Identifies a Novel Essential T3SS Substrate

J Drzmisek, D Stipl, D Petrackova, B Vecerek… - International Journal of …, 2021 - mdpi.com
Bacterial pathogens sense specific cues associated with different host niches and integrate
these signals to appropriately adjust the global gene expression. Bordetella pertussis is a …