The strain response to intraocular pressure decrease in the lamina cribrosa of patients with glaucoma

CA Czerpak, MS Kashaf, BK Zimmerman… - Ophthalmology …, 2023 - Elsevier
Objective To measure biomechanical strains in the lamina cribrosa (LC) of living human
eyes with intraocular pressure (IOP) lowering. Design Cohort study. Participants Patients …

A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography

F Zhong, B Wang, J Wei, Y Hua, B Wang, J Reynaud… - Acta biomaterialia, 2022 - Elsevier
In-vivo optic nerve head (ONH) biomechanics characterization is emerging as a promising
way to study eye physiology and pathology. We propose a high-accuracy and high …

Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy

PY Lee, B Yang, Y Hua, S Waxman, Z Zhu, F Ji… - Experimental eye …, 2022 - Elsevier
Current tools lack the temporal or spatial resolution necessary to image many important
aspects of the architecture and dynamics of the optic nerve head (ONH). We evaluated the …

IOP-induced regional displacements in the optic nerve head and correlation with peripapillary sclera thickness

Y Ma, S Kwok, J Sun, X Pan, E Pavlatos… - Experimental eye …, 2020 - Elsevier
Mechanical insult induced by intraocular pressure (IOP) is likely a driving force in the
disease process of glaucoma. This study aimed to evaluate regional displacements in …

So-called lamina cribrosa defects may mitigate IOP-induced neural tissue insult

AP Voorhees, Y Hua, BL Brazile… - … & Visual Science, 2020 - iovs.arvojournals.org
Purpose: The prevailing theory about the function of lamina cribrosa (LC) connective tissues
is that they provide structural support to adjacent neural tissues. Missing connective tissues …

Three-dimensional inflation response of porcine optic nerve head using high-frequency ultrasound elastography

Y Ma, E Pavlatos, K Clayson… - Journal of …, 2020 - asmedigitalcollection.asme.org
Abstract Characterization of the biomechanical behavior of the optic nerve head (ONH) in
response to intraocular pressure (IOP) elevation is important for understanding glaucoma …

Biomechanical Strain Responses in the Optic Nerve Head Region in Glaucoma Patients After Intraocular Pressure Lowering

Z Yuan, CA Czerpak, MS Kashaf, HA Quigley… - medRxiv, 2023 - medrxiv.org
Objective To measure strain values and their association with intraocular pressure (IOP)
change across five posterior eye regions in glaucoma patients. Design Cohort study …

Comparing acute IOP-induced lamina cribrosa deformations premortem and postmortem

J Wei, Y Hua, B Yang, B Wang… - … Vision Science & …, 2022 - tvst.arvojournals.org
Purpose: Lamina cribrosa (LC) deformations caused by elevated intraocular pressure (IOP)
are believed to contribute to glaucomatous neuropathy and have therefore been extensively …

Long-term Remodeling Response in the Lamina Cribrosa Years after Intraocular Pressure Lowering by Suturelysis after Trabeculectomy

CA Czerpak, HA Quigley, TD Nguyen - Ophthalmology Glaucoma, 2024 - Elsevier
Objective To measure the remodeling of the lamina cribrosa (LC) years after intraocular
pressure (IOP) lowering by suturelysis. Design Cohort study. Participants Glaucoma patients …

[HTML][HTML] A Noninvasive Clinical Method to Measure in Vivo Mechanical Strains of the Lamina Cribrosa by OCT

V Hannay, C Czerpak, HA Quigley, TD Nguyen - Ophthalmology Science, 2024 - Elsevier
Objective To measure mechanical strain of the lamina cribrosa (LC) after intraocular
pressure (IOP) change produced 1 week after a change in glaucoma medication. Design …