Chronic myelomonocytic leukemia: 2022 update on diagnosis, risk stratification, and management

MM Patnaik, A Tefferi - American journal of hematology, 2022 - Wiley Online Library
Abstract Disease Overview Chronic myelomonocytic leukemia (CMML) is a clonal
hematopoietic stem cell disorder with overlapping features of myelodysplastic syndromes …

[HTML][HTML] Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions

P Valent, A Orazi, MR Savona, MM Patnaik… - …, 2019 - ncbi.nlm.nih.gov
Chronic myelomonocytic leukemia (CMML) is a myeloid neoplasm characterized by
dysplasia, abnormal production and accumulation of monocytic cells and an elevated risk of …

Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia

C Elena, A Galli, E Such… - Blood, The Journal …, 2016 - ashpublications.org
Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative
neoplasm with variable clinical course. To predict the clinical outcome, we previously …

Prognostic score including gene mutations in chronic myelomonocytic leukemia

R Itzykson, O Kosmider, A Renneville… - Journal of clinical …, 2013 - ascopubs.org
Purpose Several prognostic scoring systems have been proposed for chronic
myelomonocytic leukemia (CMML), a disease in which some gene mutations—including …

Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms

L Palomo, M Meggendorfer, S Hutter… - Blood, The Journal …, 2020 - ashpublications.org
More than 90% of patients with myelodysplastic/myeloproliferative neoplasms (MDSs/MPNs)
harbor somatic mutations in myeloid-related genes, but still, current diagnostic criteria do not …

Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia

E Such, U Germing, L Malcovati… - Blood, The Journal …, 2013 - ashpublications.org
The natural course of chronic myelomonocytic leukemia (CMML) is highly variable but a
widely accepted prognostic scoring system for patients with CMML is not available. The …

ASXL1 and SETBP1 mutations and their prognostic contribution in chronic myelomonocytic leukemia: a two-center study of 466 patients

MM Patnaik, R Itzykson, TL Lasho, O Kosmider… - Leukemia, 2014 - nature.com
In a cohort of 466 patients, we sought to clarify the prognostic relevance of ASXL1 and
SETBP1 mutations, among others, in World Health Organization-defined chronic …

SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)

M Meggendorfer, A Roller, T Haferlach… - Blood, The Journal …, 2012 - ashpublications.org
We analyzed the mutational hotspot region of SRSF2 (Pro95) in 275 cases with chronic
myelomonocytic leukemia (CMML). In addition, ASXL1, CBL, EZH2, JAK2 V617F, KRAS …

Mayo prognostic model for WHO-defined chronic myelomonocytic leukemia: ASXL1 and spliceosome component mutations and outcomes

MM Patnaik, E Padron, RR LaBorde, TL Lasho… - Leukemia, 2013 - nature.com
We evaluated the prognostic relevance of several clinical and laboratory parameters in 226
Mayo Clinic patients with chronic myelomonocytic leukemia (CMML): 152 (67%) males and …

[HTML][HTML] Diagnosis and treatment of chronic myelomonocytic leukemias in adults: recommendations from the European Hematology Association and the European …

R Itzykson, P Fenaux, D Bowen, NCP Cross… - …, 2018 - journals.lww.com
Chronic myelomonocytic leukemia (CMML) is a disease of the elderly, and by far the most
frequent overlap myelodysplastic/myeloproliferative neoplasm in adults. Aside from the …