Acute-on-chronic liver failure: pathophysiological mechanisms and management

A Khanam, S Kottilil - Frontiers in medicine, 2021 - frontiersin.org
Acute-on-chronic liver failure (ACLF) is a multifaceted condition with poor treatment options
and high short-term mortality. ACLF can develop in patients with or without liver cirrhosis …

C-reactive protein: pathophysiology, diagnosis, false test results and a novel diagnostic algorithm for clinicians

DS Mouliou - Diseases, 2023 - mdpi.com
The current literature provides a body of evidence on C-Reactive Protein (CRP) and its
potential role in inflammation. However, most pieces of evidence are sparse and …

[HTML][HTML] Acute-on-chronic liver failure as a major predictive factor for mortality in patients with variceal bleeding

J Shin, JH Yu, YJ Jin, HJ Yim, YK Jung… - Clinical and …, 2020 - ncbi.nlm.nih.gov
Methods This study was retrospectively conducted on patients registered in the Korean
acute-on-chronic liver failure study cohort, and on 474 consecutive cirrhotic patients …

Survival of endogenous hepatic stem/progenitor cells in liver tissues during liver cirrhosis

Q Chen, X You, W Yang, S Jiang, J Lai, H Zhang, L Bai - Life sciences, 2020 - Elsevier
Aims This study addressed whether endogenous hepatic stem/progenitor (HSP) cells
survival were related to the injured signals during liver cirrhosis. Material and methods Liver …

[HTML][HTML] Reappraisal of sepsis-3 and CLIF-SOFA as predictors of mortality in patients with cirrhosis and infection presenting to the emergency department: A …

JH Kim, BG Jun, M Lee, HA Lee, TS Kim… - Clinical and …, 2022 - ncbi.nlm.nih.gov
Methods A total of 1,622 cirrhosis patients admitted at the ED for infections were assessed
retrospectively. We analyzed their demographic, laboratory, and microbiological data upon …

Hepatopulmonary syndrome is related to the development of acute-on-chronic liver failure and poor prognosis in cirrhotic patients

SK Han, MY Kim, SH Kang, KT Suk, SK Baik - Hepatology International, 2021 - Springer
Background and aims Long-term prospective data on hepatopulmonary syndrome (HPS)
from a large number of patients, especially in Asian patients, are lacking. We evaluated the …

Subclinical diabetes confirmed by 75‐g OGTT influence on the prognosis of decompensated cirrhosis

SH Kang, MY Kim, SK Han… - … of Gastroenterology and …, 2024 - Wiley Online Library
Background and aim Disorders of glucose metabolism, such as impaired glucose tolerance
(IGT) and diabetes mellitus (DM), frequently occur in cirrhosis. We aimed to evaluate who …

[HTML][HTML] Metabolic Dysregulation and Metabolite Imbalances in Acute-on-chronic Liver Failure: Impact on Immune Status

D Zhang, C Shi, Y Wang, J Guo… - Journal of Clinical and …, 2024 - pmc.ncbi.nlm.nih.gov
Liver failure encompasses a range of severe clinical syndromes resulting from the
deterioration of liver function, triggered by factors both within and outside the liver. While the …

[HTML][HTML] Hepatic mir-122-3p, mir-140-5p and mir-148b-5p expressions are correlated with cytokeratin-18 serum levels in MAFLD

GN López-Sánchez, E Montalvo-Javé… - Annals of …, 2022 - Elsevier
Introduction and objectives Metabolic-associated fatty liver disease (MAFLD) is defined by
steatosis in more than 5% of hepatocytes without other liver diseases. Patients with this …

[HTML][HTML] 系统性炎症反应介导慢加急性肝衰竭的研究进展

卞婷婷, 赵雷 - Advances in Clinical Medicine, 2024 - hanspub.org
慢加急性肝衰竭(ACLF) 指慢性肝病急剧恶化并出现功能障碍, 是一种伴有肝内外器官衰竭,
短期预后不佳的严重临床综合征. 虽然目前发病机制尚未完全阐明, 但可以明确系统性炎症反应 …