Microtubule dynamic instability: a new model with coupled GTP hydrolysis and multistep catastrophe
A key question in understanding microtubule dynamics is how GTP hydrolysis leads to
catastrophe, the switch from slow growth to rapid shrinkage. We first provide a review of the …
catastrophe, the switch from slow growth to rapid shrinkage. We first provide a review of the …
Regulation of microtubule growth and catastrophe: unifying theory and experiment
H Bowne-Anderson, A Hibbel, J Howard - Trends in cell biology, 2015 - cell.com
Recent studies have found that microtubule-associated proteins (MAPs) can regulate the
dynamical properties of microtubules in unexpected ways. For most MAPs, there is an …
dynamical properties of microtubules in unexpected ways. For most MAPs, there is an …
The size of the EB cap determines instantaneous microtubule stability
The function of microtubules relies on their ability to switch between phases of growth and
shrinkage. A nucleotide-dependent stabilising cap at microtubule ends is thought to be lost …
shrinkage. A nucleotide-dependent stabilising cap at microtubule ends is thought to be lost …
Molecular and mechanical causes of microtubule catastrophe and aging
Tubulin polymers, microtubules, can switch abruptly from the assembly to shortening. These
infrequent transitions, termed" catastrophes", affect numerous cellular processes but the …
infrequent transitions, termed" catastrophes", affect numerous cellular processes but the …
Structural model for differential cap maturation at growing microtubule ends
Microtubules (MTs) are hollow cylinders made of tubulin, a GTPase responsible for essential
functions during cell growth and division, and thus, key target for anti-tumor drugs. In MTs …
functions during cell growth and division, and thus, key target for anti-tumor drugs. In MTs …
Mechanisms of kinetic stabilization by the drugs paclitaxel and vinblastine
Microtubule-targeting agents (MTAs), widely used as biological probes and
chemotherapeutic drugs, bind directly to tubulin subunits and “kinetically stabilize” …
chemotherapeutic drugs, bind directly to tubulin subunits and “kinetically stabilize” …
Self-assembling outside equilibrium: emergence of structures mediated by dissipation
A Arango-Restrepo, D Barragán… - Physical Chemistry …, 2019 - pubs.rsc.org
A set of disordered interacting building blocks may form ordered structures by means of a
self-assembling process. An external intervention in the system by adding a chemical …
self-assembling process. An external intervention in the system by adding a chemical …
Microtubule length regulation by molecular motors
Length regulation of microtubules (MTs) is essential for many cellular processes. Molecular
motors like kinesin-8, which move along MTs and also act as depolymerases, are known as …
motors like kinesin-8, which move along MTs and also act as depolymerases, are known as …
Semiflexible chains at surfaces: Worm-like chains and beyond
J Baschnagel, H Meyer, J Wittmer, I Kulić, H Mohrbach… - Polymers, 2016 - mdpi.com
We give an extended review of recent numerical and analytical studies on semiflexible
chains near surfaces undertaken at Institut Charles Sadron (sometimes in collaboration) with …
chains near surfaces undertaken at Institut Charles Sadron (sometimes in collaboration) with …
Reaction kinetics in open reactors and serial transfers between closed reactors
Kinetic theory and thermodynamics of reaction networks are extended to the out-of-
equilibrium dynamics of continuous-flow stirred tank reactors (CSTR) and serial transfers …
equilibrium dynamics of continuous-flow stirred tank reactors (CSTR) and serial transfers …