In this review, we highlight the current understanding of translation elongation and recoding
in eukaryotes. In addition to providing an overview of the process, recent advances in our …

In this review, we provide an overview of protein synthesis in the yeast Saccharomyces
cerevisiae. The mechanism of protein synthesis is well conserved between yeast and other …

Abstract eIF5A is an essential protein involved in protein synthesis, cell proliferation and
animal development. High eIF5A expression is observed in many tumor types and has been …

The eukaryotic translation initiation factor 5A (eIF5A) is an evolutionarily conserved protein
that binds ribosomes to facilitate the translation of peptide motifs with consecutive prolines or …

The eukaryotic translation factor, eIF5A has been recently reported as a sequence-specific
elongation factor that facilitates peptide bond formation at consecutive prolines in …

DHPS deficiency syndrome is an ultra-rare neurodevelopmental disorder (NDD) which
results from biallelic mutations in the gene encoding the enzyme deoxyhypusine synthase …

Abstract Background Eukaryotic Initiation Factor 5A (eIF-5A), an essential translation factor,
is post-translationally activated by the polyamine spermidine. Two human genes encode eIF …

Iron is an essential element for all eukaryotes, since it acts as a cofactor for many enzymes
involved in basic cellular functions, including translation. While the mammalian iron …

Translation elongation factor eIF5A binds to ribosomes to promote peptide bonds between
problematic amino acids for the reaction like prolines. eIF5A is highly conserved and …

Mitochondrial activity adapts to cellular energetic and metabolic demands; its dysfunction is
a hallmark of ageing and many human diseases. The evolutionarily conserved translation …