Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers

EV Batrakova, AV Kabanov - Journal of controlled release, 2008 - Elsevier
Polymer nanomaterials have sparked a considerable interest as vehicles used for diagnostic
and therapeutic agents; research in nanomedicine has not only become a frontier movement …

Pluronic F127-based thermosensitive gels for delivery of therapeutic proteins and peptides

MSH Akash, K Rehman, S Chen - Polymer Reviews, 2014 - Taylor & Francis
Pluronic F127 block copolymer (PF127) has been recognized as an important biomaterial
used for the efficient delivery of therapeutic proteins and peptides against various incurable …

Surface engineered polymeric nanocarriers mediate the delivery of transferrin–methotrexate conjugates for an improved understanding of brain cancer

A Jain, A Jain, NK Garg, RK Tyagi, B Singh, OP Katare… - Acta biomaterialia, 2015 - Elsevier
The objective of present study was to enhance permeation of bioactive molecules across
blood brain barrier (BBB) through polysorbate 80 coated poly-lactic-co-glycolic acid (PLGA) …

Effects of pluronic and doxorubicin on drug uptake, cellular metabolism, apoptosis and tumor inhibition in animal models of MDR cancers

EV Batrakova, S Li, AM Brynskikh, AK Sharma… - Journal of controlled …, 2010 - Elsevier
Cancer chemotherapy is believed to be impeded by multidrug resistance (MDR). Pluronic
(triblock copolymers of poly (ethylene oxide)(PEO) and poly (propylene oxide)(PPO), PEO-b …

Hyaluronic acid coated Pluronic F127/Pluronic P123 mixed micelle for targeted delivery of Paclitaxel and Curcumin

TS Anirudhan, S Varghese, V Manjusha - International journal of biological …, 2021 - Elsevier
The hydrophobicity of most of the anticancer drugs offers a great challenge in selecting a
system for their effective transport. Here comes the importance of micelles that offers a …

Formulation and characterization of echogenic lipid− pluronic nanobubbles

TM Krupka, L Solorio, RE Wilson, H Wu… - Molecular …, 2010 - ACS Publications
The advent of microbubble contrast agents has enhanced the capabilities of ultrasound as a
medical imaging modality and stimulated innovative strategies for ultrasound-mediated drug …

Micelles, mixed micelles, and applications of polyoxypropylene (PPO)-polyoxyethylene (PEO)-polyoxypropylene (PPO) triblock polymers

V Singh, P Khullar, PN Dave, N Kaur - International Journal of Industrial …, 2013 - Springer
This review gives a brief outline of various micellar properties of triblock polymers such as
critical micellization concentration, critical micellization temperature, and microviscosity …

Key structure of brij for overcoming multidrug resistance in cancer

J Tang, Y Wang, D Wang, Y Wang, Z Xu… - …, 2013 - ACS Publications
Multidrug resistance (MDR) is a major barrier to the chemotherapy treatment of many
cancers. However, some nonionic surfactants, for example, Brij, have been shown to restore …

Drug-eluting polymer implants in cancer therapy

AA Exner, GM Saidel - Expert opinion on drug delivery, 2008 - Taylor & Francis
Background: Drug-eluting polymer implants present a compelling parenteral route of
administration for cancer chemotherapy. With potential for minimally invasive, image-guided …

Intratumoral injection of thermogelling and sustained-release carboplatin-loaded hydrogel simplifies the administration and remains the synergistic effect with …

HKT Liang, XS Lai, MF Wei, SH Lu, WF Wen, SH Kuo… - Biomaterials, 2018 - Elsevier
Background Carboplatin, an antineoplastic agent, binds DNA and enhances radiotherapy
(RT) effects. Carboplatin-loaded hydrogel (oxidized hyaluronic acid/adipic acid dihydrazide) …