Calcium signalling: dynamics, homeostasis and remodelling
MJ Berridge, MD Bootman, HL Roderick - Nature reviews Molecular …, 2003 - nature.com
Ca 2+ is a highly versatile intracellular signal that operates over a wide temporal range to
regulate many different cellular processes. An extensive Ca 2+-signalling toolkit is used to …
regulate many different cellular processes. An extensive Ca 2+-signalling toolkit is used to …
TRP channels
K Venkatachalam, C Montell - Annu. Rev. Biochem., 2007 - annualreviews.org
Abstract The TRP (Transient Receptor Potential) superfamily of cation channels is
remarkable in that it displays greater diversity in activation mechanisms and selectivities …
remarkable in that it displays greater diversity in activation mechanisms and selectivities …
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
SM Nauli, FJ Alenghat, Y Luo, E Williams, P Vassilev… - Nature …, 2003 - nature.com
Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize
to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw …
to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw …
Autosomal dominant polycystic kidney disease
VE Torres, PC Harris, Y Pirson - The Lancet, 2007 - thelancet.com
Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal,
monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which …
monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which …
Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease
PC Harris, VE Torres - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
Recent advances in defining the genetic mechanisms of disease causation and modification
in autosomal dominant polycystic kidney disease (ADPKD) have helped to explain some …
in autosomal dominant polycystic kidney disease (ADPKD) have helped to explain some …
Polycystic kidney disease
PC Harris, VE Torres - Annual review of medicine, 2009 - annualreviews.org
A number of inherited disorders result in renal cyst development. The most common form,
autosomal dominant polycystic kidney disease (ADPKD), is a disorder most often diagnosed …
autosomal dominant polycystic kidney disease (ADPKD), is a disorder most often diagnosed …
The ciliopathies: an emerging class of human genetic disorders
Cilia and flagella are ancient, evolutionarily conserved organelles that project from cell
surfaces to perform diverse biological roles, including whole-cell locomotion; movement of …
surfaces to perform diverse biological roles, including whole-cell locomotion; movement of …
The TRP superfamily of cation channels
C Montell - Science's STKE, 2005 - science.org
The transient receptor potential (TRP) protein superfamily consists of a diverse group of
cation channels that bear structural similarities to Drosophila TRP. TRP channels play …
cation channels that bear structural similarities to Drosophila TRP. TRP channels play …
Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium
Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic
Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a …
Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a …
Two populations of node monocilia initiate left-right asymmetry in the mouse
J McGrath, S Somlo, S Makova, X Tian, M Brueckner - Cell, 2003 - cell.com
The vertebrate body plan has conserved handed left-right (LR) asymmetry that is manifested
in the heart, lungs, and gut. Leftward flow of extracellular fluid at the node (nodal flow) is …
in the heart, lungs, and gut. Leftward flow of extracellular fluid at the node (nodal flow) is …