Myeloproliferative neoplasms and thrombosis

T Barbui, G Finazzi, A Falanga - Blood, The Journal of the …, 2013 - ashpublications.org
Major causes of morbidity and mortality in myeloproliferative neoplasms are represented by
arterial and venous complications, progression to myelofibrosis, and transformation to acute …

The neutrophil's choice: phagocytose vs make neutrophil extracellular traps

AA Manfredi, GA Ramirez, P Rovere-Querini… - Frontiers in …, 2018 - frontiersin.org
Neutrophils recognize particulate substrates of microbial or endogenous origin and react by
sequestering the cargo via phagocytosis or by releasing neutrophil extracellular traps …

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

J Perdomo, HHL Leung, Z Ahmadi, F Yan… - Nature …, 2019 - nature.com
Heparin-induced thrombocytopenia/thrombosis (HIT) is a serious immune reaction to
heparins, characterized by thrombocytopenia and often severe thrombosis with high …

[HTML][HTML] Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

N Maugeri, L Campana, M Gavina, C Covino… - Journal of Thrombosis …, 2014 - Elsevier
Background Increasing evidence implicates both platelets and neutrophils in the formation,
stabilization, and growth of peripheral and coronary thrombi. Neutrophil extracellular traps …

Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes

MJ Kraakman, MKS Lee, A Al-Sharea… - The Journal of …, 2017 - Am Soc Clin Investig
Platelets play a critical role in atherogenesis and thrombosis-mediated myocardial ischemia,
processes that are accelerated in diabetes. Whether hyperglycemia promotes platelet …

[HTML][HTML] Unconventional CD147‐dependent platelet activation elicited by SARS‐CoV‐2 in COVID‐19

N Maugeri, R De Lorenzo, N Clementi, RA Diotti… - Journal of Thrombosis …, 2022 - Elsevier
Background Platelet activation and thrombotic events characterizes COVID‐19. Objectives
To characterize platelet activation and determine if SARS‐CoV‐2 induces platelet activation …

Platelet activation markers in evaluation of thrombotic risk factors in various clinical settings

M Kannan, F Ahmad, R Saxena - Blood reviews, 2019 - Elsevier
Platelets play a major role in primary hemostasis and thrombus formation. After vascular
injury, platelets adhere to injured site and rapidly change their shape that switches the …

New perspectives on polycythemia vera: from diagnosis to therapy

A Iurlo, D Cattaneo, C Bucelli, L Baldini - International Journal of …, 2020 - mdpi.com
Polycythemia vera (PV) is mainly characterized by elevated blood cell counts, thrombotic as
well as hemorrhagic predisposition, a variety of symptoms, and cumulative risks of fibrotic …

Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps

AA Manfredi, P Rovere-Querini, A D'Angelo… - Pharmacological …, 2017 - Elsevier
The protection exerted by neutrophils against invading microbes is partially mediated via the
generation of neutrophil extracellular traps (NETs). In sterile conditions NETs are damaging …

Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine-induced thrombotic thrombocytopenia (VITT)

J Kashir, AR Ambia, A Shafqat, MR Sajid… - Journal of leukocyte …, 2022 - academic.oup.com
Following on from the devastating spread of COVID-19, a major global priority has been the
production, procurement, and distribution of effective vaccines to ensure that the global …