New insights in prolactin: pathological implications

V Bernard, J Young, P Chanson, N Binart - Nature Reviews …, 2015 - nature.com
Prolactin is a hormone that is mainly secreted by lactotroph cells of the anterior pituitary
gland, and is involved in many biological processes including lactation and reproduction …

Animal models of diabetic retinopathy: summary and comparison

AKW Lai, ACY Lo - Journal of diabetes research, 2013 - Wiley Online Library
Diabetic retinopathy (DR) is a microvascular complication associated with chronic exposure
to hyperglycemia and is a major cause of blindness worldwide. Although clinical …

Neurodegeneration in the pathogenesis of diabetic retinopathy: molecular mechanisms and therapeutic implications

M S. Stem, T W. Gardner - Current medicinal chemistry, 2013 - benthamdirect.com
Diabetic retinopathy (DR), commonly classified as a microvascular complication of diabetes,
is now recognized as a neurovascular complication or sensory neuropathy resulting from …

[HTML][HTML] Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-Seq

SS Whitmore, AH Wagner, AP DeLuca, AV Drack… - Experimental eye …, 2014 - Elsevier
Proper spatial differentiation of retinal cell types is necessary for normal human vision. Many
retinal diseases, such as Best disease and male germ cell associated kinase (MAK) …

Regulation of blood vessels by prolactin and vasoinhibins

C Clapp, S Thebault, Y Macotela… - Recent Advances in …, 2015 - Springer
Prolactin (PRL) stimulates the growth of new blood vessels (angiogenesis) either directly
through actions on endothelial cells or indirectly by upregulating proangiogenic factors like …

Endothelial progenitor cells in diabetic retinopathy

N Lois, RV McCarter, C O'Neill, RJ Medina… - Frontiers in …, 2014 - frontiersin.org
Diabetic retinopathy (DR) is a leading cause of visual impairment worldwide. Patients with
DR may irreversibly lose sight as a result of the development of diabetic macular edema …

Prolactin and teleost ionocytes: new insights into cellular and molecular targets of prolactin in vertebrate epithelia

JP Breves, SD McCormick, RO Karlstrom - General and comparative …, 2014 - Elsevier
The peptide hormone prolactin is a functionally versatile hormone produced by the
vertebrate pituitary. Comparative studies over the last six decades have revealed that a …

Prolactin effects on the pathogenesis of diabetes mellitus

R Scairati, RS Auriemma, G Del Vecchio… - European Journal of …, 2024 - Wiley Online Library
Background Prolactin (PRL) is a pituitary hormone promoting lactation in response to the
suckling reflex. Beyond its well‐known effects, novel tissue‐specific and metabolic functions …

Prolactin protects retinal pigment epithelium by inhibiting sirtuin 2-dependent cell death

RM García, DA Zamarripa, E Arnold, X Ruiz-Herrera… - …, 2016 - thelancet.com
The identification of pathways necessary for retinal pigment epithelium (RPE) function is
fundamental to uncover therapies for blindness. Prolactin (PRL) receptors are expressed in …

Principles of the prolactin/vasoinhibin axis

J Triebel, T Bertsch, C Bollheimer… - American Journal …, 2015 - journals.physiology.org
The hormonal family of vasoinhibins, which derive from the anterior pituitary hormone
prolactin, are known for their inhibiting effects on blood vessel growth, vasopermeability, and …