Liver fluke infection caused by Opisthorchis viverrini is a major public health problem in
Thailand and adjacent countries. In addition to infection-associated morbidity, infection with …

The growth factor progranulin (PGRN) regulates cell division, survival, and migration. PGRN
is an extracellular glycoprotein bearing multiple copies of the cysteine‐rich granulin motif …

Review on the role of progranulin in immunity, infection, and inflammation, and its
therapeutic potential in treating inflammatory conditions. PGRN, a pleiotrophic growth factor …

Immune evasion is indispensable for cancer initiation and progression, although its
underlying mechanisms in pancreatic ductal adenocarcinoma (PDAC) are not fully known …

Heterozygous, loss-of-function mutations in the granulin gene (GRN) encoding progranulin
(PGRN) are a common cause of frontotemporal dementia (FTD). Homozygous GRN …

Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene.
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …

Although the growth factor progranulin was discovered more than two decades ago, the
functional receptor remains elusive. Here, we discovered that EphA2, a member of the large …

GRN mutations cause frontotemporal lobar degeneration with TDP-43-positive inclusions.
The mechanism of pathogenesis is haploinsufficiency. Recently, homozygous GRN …

The human liver fluke, Opisthorchis viverrini, infects millions of people throughout south-east
Asia and is a major cause of cholangiocarcinoma, or cancer of the bile ducts. The …

Epithelial–mesenchymal transition is a physiopathological process by which epithelial cells
acquire mesenchymal shape and properties. Malignant mesothelioma is histologically …