[HTML][HTML] Fluid dynamics in aging-related dementias

TM Bah, DA Siler, AH Ibrahim, JS Cetas… - Neurobiology of …, 2023 - Elsevier
Recent human and animal model experimental studies revealed novel pathways for fluid
movement, immune cell trafficking and metabolic waste clearance in CNS. These studies …

Venous hemodynamics in neurological disorders: an analytical review with hydrodynamic analysis

CB Beggs - BMC medicine, 2013 - Springer
Venous abnormalities contribute to the pathophysiology of several neurological conditions.
This paper reviews the literature regarding venous abnormalities in multiple sclerosis (MS) …

Thalamic atrophy is associated with development of clinically definite multiple sclerosis

R Zivadinov, E Havrdová, N Bergsland, M Tyblova… - Radiology, 2013 - pubs.rsna.org
Purpose To investigate the association between the development of thalamic and cortical
atrophy and the conversion to clinically definite multiple sclerosis (CDMS) in patients with …

Dynamic 11C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer disease and multiple sclerosis

JJ Schubert, M Veronese, L Marchitelli… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Cerebrospinal fluid (CSF) plays an important role in solute clearance and maintenance of
brain homeostasis. 11C-Pittsburgh compound B (PiB) PET was recently proposed as a tool …

Albumin and multiple sclerosis

SM LeVine - BMC neurology, 2016 - Springer
Leakage of the blood–brain barrier (BBB) is a common pathological feature in multiple
sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in …

Brain venous haemodynamics, neurological diseases and mathematical modelling. A review

EF Toro - Applied Mathematics and Computation, 2016 - Elsevier
Abstract Behind Medicine (M) is Physiology (P), behind Physiology is Physics (P) and
behind Physics is always Mathematics (M), for which I expect that the symmetry of the …

Enhanced global mathematical model for studying cerebral venous blood flow

LO Müller, EF Toro - Journal of biomechanics, 2014 - Elsevier
Here we extend the global, closed-loop, mathematical model for the cardiovascular system
in Müller and Toro (2014) to account for fundamental mechanisms affecting cerebral venous …

Efficacy and safety of extracranial vein angioplasty in multiple sclerosis: a randomized clinical trial

P Zamboni, L Tesio, S Galimberti, L Massacesi… - JAMA …, 2018 - jamanetwork.com
Importance Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by
restricted venous outflow from the brain and spinal cord. Whether this condition is …

Potential involvement of the extracranial venous system in central nervous system disorders and aging

R Zivadinov, CP Chung - BMC medicine, 2013 - Springer
Background The role of the extracranial venous system in the pathology of central nervous
system (CNS) disorders and aging is largely unknown. It is acknowledged that the …

Impairment of spinal CSF flow precedes immune cell infiltration in an active EAE model

L Xin, A Madarasz, DC Ivan, F Weber… - Journal of …, 2024 - Springer
Accumulation of immune cells and proteins in the subarachnoid space (SAS) is found during
multiple sclerosis and in the animal model experimental autoimmune encephalomyelitis …