All organisms possess molecular mechanisms that govern DNA repair and associated DNA
damage response (DDR) processes. Owing to their relevance to human disease, most …

Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and
require repair by multiple pathways. Whether transcription blockage contributes to the …

DNA damages compromise cell function and fate. Cells of all organisms activate a global
DNA damage response that includes a signaling stress response, activation of checkpoints …

DNA–protein crosslinks (DPCs) are highly toxic DNA lesions that are relevant to multiple
human diseases. They are caused by various endogenous and environmental agents, and …

Transcription coupled-nucleotide excision repair (TC-NER) removes DNA lesions that block
RNA polymerase II (Pol II) transcription. A key step in TC-NER is the recruitment of the TFIIH …

All organisms possess molecular mechanisms that govern DNA repair and associated DNA-
damage response (DDR) processes. Owing to their relevance to human disease, most …