Subunit-selective PI3-kinase control of action strategies in the medial prefrontal cortex

RA Davies, BR Barbee, Y Garcia-Sifuentes… - … of Learning and …, 2023 - Elsevier
Abstract PI3-kinase (PI3K) is an intracellular signaling complex that is stimulated upon
cocaine exposure and linked with the behavioral consequences of cocaine. We recently …

Prefrontal circHomer1 regulates synaptic and behavioral adaptations induced by psychostimulants

J Shi, Y Chen, Z Zhang, X Li, W Chen, S Huang… - 2024 - researchsquare.com
Substance use disorder (SUD) represents a substantial challenge in neuropsychiatric
medicine, with the molecular mechanisms underlying its etiology remaining elusive. The …

A dubious distinction for females: rapid achievement of prefrontal cortical hypoactivity and cognitive deficit upon remifentanil self-administration

SL Gourley - Neuropsychopharmacology, 2021 - nature.com
Humans have long ingested opioids. In 1797, an opium-induced dream inspired Samuel
Taylor Coleridge's famous poem “Kubla Khan”. 100 years later, Arthur Conan Doyle's …

PI3-Kinase p110β in Cortical Circuitries and Cocaine-Dependent Maladaptive Behaviors

Y Ehinger - Biological Psychiatry, 2021 - biologicalpsychiatryjournal.com
In 2019, around 5.5 million individuals in the United States were cocaine users and 1 million
people exhibited cocaine use disorder (CUD) phenotypes (1). CUD is associated with …