Neurodegenerative diseases as diverse as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease share a common pathogenetic mechanism involving aggregation and deposition of …
D Shea, CC Hsu, TM Bi, N Paranjapye… - Proceedings of the …, 2019 - National Acad Sciences
Alzheimer's disease (AD) is characterized by the deposition of β-sheet–rich, insoluble amyloid β-peptide (Aβ) plaques; however, plaque burden is not correlated with cognitive …
WB Stine, L Jungbauer, C Yu, MJ LaDu - Alzheimer's Disease and …, 2011 - Springer
This chapter outlines protocols that produce homogenous preparations of oligomeric and fibrillar amyloid-β peptide (Aβ). While there are several isoforms of this peptide, the 42 …
LP Wu, D Ahmadvand, J Su, A Hall, X Tan… - Nature …, 2019 - nature.com
The filamentous bacteriophage fd bind a cell target with exquisite specificity through its few copies of display peptides, whereas nanoparticles functionalized with hundreds to …
A Sandberg, LM Luheshi… - Proceedings of the …, 2010 - National Acad Sciences
Soluble oligomeric aggregates of the amyloid-β peptide (Aβ) have been implicated in the pathogenesis of Alzheimer's disease (AD). Although the conformation adopted by Aβ within …
Copper is a redox-active metal with many important biological roles. Consequently, its distribution and oxidation state are subject to stringent regulation. A large body of …
VH Finder, R Glockshuber - Neurodegenerative Diseases, 2007 - karger.com
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of …
M Hoshi, M Sato, S Matsumoto… - Proceedings of the …, 2003 - National Acad Sciences
β-Amyloid (Aβ) acquires toxicity by self-aggregation. To identify and characterize the toxic form (s) of Aβ aggregates, we examined in vitro aggregation conditions by using large …