HLA-DR15 Haplotype and Multiple Sclerosis: A HuGE Review
H Schmidt, D Williamson… - American journal of …, 2007 - academic.oup.com
An association between multiple sclerosis (MS) and the human leukocyte antigen (HLA)
complex, a dense cluster of genes on the short arm of chromosome 6, was first noted over …
complex, a dense cluster of genes on the short arm of chromosome 6, was first noted over …
The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis
VK Tuohy, M Yu, L Yin, JA Kawczak… - Immunological …, 1998 - Wiley Online Library
We have made the following observations regarding self‐recognition during the
development and progression of murine experimental autoimmune encephalomyelitis (EAE) …
development and progression of murine experimental autoimmune encephalomyelitis (EAE) …
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
The human leukocyte antigen (HLA) haplotype DRB1* 15: 01 is the major risk factor for
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …
Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects
NA Patsopoulos, LF Barcellos, RQ Hintzen… - PLoS …, 2013 - journals.plos.org
The major histocompatibility complex (MHC) region is strongly associated with multiple
sclerosis (MS) susceptibility. HLA-DRB1* 15: 01 has the strongest effect, and several other …
sclerosis (MS) susceptibility. HLA-DRB1* 15: 01 has the strongest effect, and several other …
Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies
This paper presents a meta-analysis of high-resolution human leukocyte antigen (HLA)
allele frequency data describing 497 population samples. Most of the datasets were …
allele frequency data describing 497 population samples. Most of the datasets were …
Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans
JR Oksenberg, LF Barcellos, BAC Cree… - The American Journal of …, 2004 - cell.com
An underlying complex genetic susceptibility exists in multiple sclerosis (MS), and an
association with the HLA-DRB1* 1501-DQB1* 0602 haplotype has been repeatedly …
association with the HLA-DRB1* 1501-DQB1* 0602 haplotype has been repeatedly …
HLA‐DR15 is associated with lower age at onset in multiple sclerosis
T Masterman, A Ligers, T Olsson… - Annals of Neurology …, 2000 - Wiley Online Library
To date, more than a dozen studies have investigated the role of HLA genes in determining
clinical course and disease severity in multiple sclerosis (MS); in each of these studies …
clinical course and disease severity in multiple sclerosis (MS); in each of these studies …
[图书][B] ДНК-диагностика и медико-генетическое консультирование в неврологии
СН Иллариошкин, ИА Иванова-Смоленская… - 2002 - elibrary.ru
Монография посвящена современным возможностям ДНК-диагностики и основанного
на ней медико-генетического консультирования при наследственных заболеваниях …
на ней медико-генетического консультирования при наследственных заболеваниях …
Bioinformatics and system biology approaches to identify pathophysiological impact of COVID-19 to the progression and severity of neurological diseases
Abstract The Coronavirus Disease 2019 (COVID-19) still tends to propagate and increase
the occurrence of COVID-19 across the globe. The clinical and epidemiological analyses …
the occurrence of COVID-19 across the globe. The clinical and epidemiological analyses …
Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease
Elucidating the cellular immune response to infectious agents is a prerequisite for
understanding disease pathogenesis and designing effective vaccines. In the identification …
understanding disease pathogenesis and designing effective vaccines. In the identification …