There exists a paucity of structural innovation and limited molecular diversity associated with
molecular frameworks in drug discovery and biomolecular imaging/chemical probe design …

The [2+ 2] photocycloaddition is undisputedly the most important and most frequently used
photochemical reaction. In this review, it is attempted to cover all recent aspects of [2+ 2] …

In this review, the history of boron's early use in drugs, and the history of the use of boron
functional groups in medicinal chemistry applications are discussed. This includes …

Icosahedral carboranes in medicine are still an emerging class of compounds with potential
beneficial applications in drug design. These highly hydrophobic clusters are potential “new …

Microglial activation is a distinguished attribute in many neurodegenerative diseases of
aging. Compelling evidence suggests that neuroinflammation stimulated by microglia, the …

There are two branches in boron medicinal chemistry: the first focuses on single boron atom
compounds, and the second utilizes boron clusters. Boron clusters and their heteroatom …

A standard goal of medicinal chemists has been to discover efficient and potent drug
candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive …

The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a
potential drug target because of its widespread involvement in inflammatory diseases as a …

Pharmacological tool compounds are now available to define action at the adenosine (ARs),
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …

Which elements are essential for human life? Here we make an element-by-element journey
through the periodic table and attempt to assess whether elements are essential or not, and …