Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis

T Olsson, LF Barcellos, L Alfredsson - Nature Reviews Neurology, 2017 - nature.com
Genetic predisposition to multiple sclerosis (MS) only explains a fraction of the disease risk;
lifestyle and environmental factors are key contributors to the risk of MS. Importantly, these …

Environmental and genetic risk factors for MS: an integrated review

E Waubant, R Lucas, E Mowry, J Graves… - Annals of clinical …, 2019 - Wiley Online Library
Recent findings have provided a molecular basis for the combined contributions of
multifaceted risk factors for the onset of multiple sclerosis (MS). MS appears to start as a …

Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

TV Lanz, RC Brewer, PP Ho, JS Moon, KM Jude… - Nature, 2022 - nature.com
Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive
lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the …

Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis

OG Thomas, M Bronge, K Tengvall, B Akpinar… - Science …, 2023 - science.org
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, for which
Epstein-Barr virus (EBV) infection is a likely prerequisite. Due to the homology between …

Conversion from clinically isolated syndrome to multiple sclerosis: a large multicentre study

J Kuhle, G Disanto, R Dobson… - Multiple Sclerosis …, 2015 - journals.sagepub.com
Background and objective: We explored which clinical and biochemical variables predict
conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis …

Lifestyle and environmental factors in multiple sclerosis

L Alfredsson, T Olsson - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Lifestyle and environmental factors potently influence the risk of multiple sclerosis (MS),
because genetic predisposition only explains a fraction of the risk increase. There is strong …

Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk

K Tengvall, J Huang, C Hellström… - Proceedings of the …, 2019 - National Acad Sciences
Multiple sclerosis (MS) is a chronic inflammatory, likely autoimmune disease of the central
nervous system with a combination of genetic and environmental risk factors, among which …

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to: in vivo: imaging

Y Guan, D Jakimovski, M Ramanathan… - Neural regeneration …, 2019 - journals.lww.com
Multiple sclerosis (MS) is a disease of the central nervous system characterized by
inflammation, demyelination, and neuronal damage. Environmental and genetic factors are …

The Swedish MS registry–clinical support tool and scientific resource

J Hillert, L Stawiarz - Acta Neurologica Scandinavica, 2015 - Wiley Online Library
The Swedish MS registry (SMS reg) is designed to assure quality health care for patients
with multiple sclerosis (MS). It has been active since 2001 and web‐based since 2004. It …

Multiple sclerosis risk factors and pathogenesis

B Nourbakhsh, EM Mowry - CONTINUUM: Lifelong Learning in …, 2019 - journals.lww.com
PURPOSE OF REVIEW This article summarizes recent advances in the identification of
genetic and environmental factors that affect the risk of developing multiple sclerosis (MS) …