OBJECTIVE: To review the concept of chirality and its current role in the pharmacology of
antiallergic, antiasthmatic, and immunologic agents. DATA SOURCES: Ovid MEDLINE and …

Local anesthetics inhibit binding of ligands to beta 2-adrenergic receptors (beta 2 ARs), and,
as a consequence, inhibit intracellular cAMP production. We hypothesized that among …

This study examines the stereoselectivity profile of recombinant mouse, rat and human β3-
adrenoceptors expressed in Chinese Hamster Ovary (CHO-K1) cells using radioligand …

The chemical specificity for the β-adrenoceptor mediated relaxation of rat esophageal
smooth muscle was evaluated using selective and non-selective β-adrenoceptor agonists …

Trimetoquinol (TMQ, 1) is a potent non-selective β-adrenoceptor (β-AR) agonist possessing
a tetrahydroisoquinoline (THI) structure. The binding site for 1-trimethoxybenzyl group of 1 …

Trimetoquinol (TMQ, 7) is a potent nonselective β-adrenoceptor (AR) agonist. Replacement
of the catechol moiety of TMQ with a 2-aminothiazole group resulted in novel …

The β-adrenoceptor activities of trimetoquinol (TMQ) isomers and selected derivatives were
evaluated on human β-adrenoceptor subtypes expressed in Chinese hamster ovary cells. In …

Trimetoquinol (1, TMQ) is a potent nonselective β-adrenergic receptor (AR) agonist and a
thromboxane A2/prostaglandin endoperoxide (TP) receptor antagonist, while 3 ', 5 '-diiodo …

The β-adrenoceptor activity profile of trimetoquinol and its 1-benzyl halogen-substituted
analogues was studied in rat tissues containing primarily β1 (atria)-, β2 (trachea)-and …

Since the first pharmacological description of an'atypical'adrenoreceptor and the cloning of
theAR gene, research interest in this receptor has grown considerably and many advances …