Synapses, as fundamental units of the neural circuitry, enable complex behaviors. The
neuromuscular junction (NMJ) is a synapse type that forms between motoneurons and …

Podosomes and invadopodia are unique actin-rich adhesions that establish close contact to
the substratum but can also degrade components of the extracellular matrix. Accordingly …

Smooth muscle cell migration occurs during vascular development, in response to vascular
injury, and during atherogenesis. Many proximal signals and signal transduction pathways …

Phospholipase D is a ubiquitous class of enzymes that generates phosphatidic acid as an
intracellular signaling species. The phospholipase D superfamily plays a central role in a …

The releasable factor adenosine blocks the formation of long-term potentiation (LTP). These
experiments used this observation to uncover the synaptic processes that stabilize the …

Since its discovery in the early 1990's, cortactin has emerged as a key signaling protein in
many cellular processes, including cell adhesion, migration, endocytosis, and tumor …

Rho family GTPases control cell migration and participate in the regulation of cancer
metastasis. Invadopodia, associated with invasive tumour cells, are crucial for cellular …

The p21-activated kinase (PAK) family of serine/threonine kinases is important in
physiological processes including motility, survival, mitosis, transcription and translation …

Branched actin assembly is critical for a variety of cellular processes that underlie cell
motility and invasion, including cellular protrusion formation and membrane trafficking …

Weaver, 2008). Cortactin was first identified as a prominent substrate of the Src nonreceptor
tyrosine kinase. Its name was derived from the observation that cortactin localizes to cortical …