Immunology of IL-12: An update on functional activities and implications for disease

KAM Ullrich, LL Schulze, EM Paap, TM Müller… - EXCLI …, 2020 - pmc.ncbi.nlm.nih.gov
As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In
response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and …

PPARG (Pro12Ala) genetic variant and risk of T2DM: a systematic review and meta-analysis

N Sarhangi, F Sharifi, L Hashemian… - Scientific reports, 2020 - nature.com
Type 2 diabetes mellitus (T2DM) is a complex disease caused by the interaction between
genetic and environmental factors. A growing number of evidence suggests that the …

[HTML][HTML] Precision diabetes is slowly becoming a reality

V Mohan, V Radha - Medical Principles and Practice, 2019 - karger.com
The concept of precision medicine is becoming increasingly popular. The use of big data,
genomics and other “omics” like metabolomics, proteomics and transcriptomics could make …

[HTML][HTML] Precision medicine in non communicable diseases

M Hasanzad, N Sarhangi, HRA Meybodi… - … Journal of Molecular …, 2019 - ncbi.nlm.nih.gov
Non-communicable diseases (NCDs) are the leading cause of death and disease burden
globally, cardiovascular diseases (CVDs) account for the major part of death related to …

Predictive biomarkers for type 2 of diabetes mellitus: Bridging the gap between systems research and personalized medicine

C Kraniotou, V Karadima, G Bellos, GT Tsangaris - Journal of proteomics, 2018 - Elsevier
The global incidence of metabolic disorders like type 2 diabetes mellitus (DM2) has
assumed epidemic proportions, leading to adverse health and socio-economic impacts. It is …

Pharmacogenetics of oral antidiabetic therapy

AM Ordelheide, M Hrabě de Angelis… - …, 2018 - Taylor & Francis
Type 2 diabetes prevalence is still on the rise worldwide. Antidiabetic drugs are widely
prescribed to patients with Type 2 diabetes. Most patients start with metformin which is …

ANRIL's Epigenetic Regulation and Its Implications for Cardiovascular Disorders

E Moglad, P Kaur, SV Menon, Abida… - … of Biochemical and …, 2024 - Wiley Online Library
Cardiovascular disorders (CVDs) are a major global health concern, but their underlying
molecular mechanisms are not fully understood. Recent research highlights the role of long …

Introducing Mobile Collaborative Robots into Bioprocessing Environments: Personalised Drug Manufacturing and Environmental Monitoring

R Mathew, R McGee, K Roche, S Warreth… - Applied Sciences, 2022 - mdpi.com
Personalised therapeutic drugs are the future of the medical drug sector. For manufacturers,
this will require the flexibility to produce many different unique batches within a given facility …

Precision medicine in infectious disease

MJR Alvarez, M Hasanzad, HRA Meybodi… - Precision medicine in …, 2022 - Springer
The conception that several infectious diseases were linked to an inherited disorder has
been discussed, and every day, substantial evidence now is supported by the human …

Machine-learning models utilizing CYP3A4*1G show improved prediction of hypoglycemic medication in Type 2 diabetes

Y Yang, X Hou, W Ge, X Wang, Y Xu, W Chen… - Personalized …, 2023 - Taylor & Francis
The effectiveness and side effects of Type 2 diabetes (T2D) medication are related to
individual genetic background. SNPs CYP3A4 and CYP2C19 were introduced to machine …