[HTML][HTML] Unmasking the hidden impact of viruses on tuberculosis risk

F Darboe, JF Reijneveld, DP Maison, L Martinez… - Trends in …, 2024 - cell.com
Tuberculosis (TB) is a leading cause of mortality from an infectious disease. In this opinion
article, we focus on accumulating scientific evidence indicating that viral infections may …

[HTML][HTML] Post-Acute sequelae and mitochondrial aberration in SARS-CoV-2 infection

C Ward, B Schlichtholz - International Journal of Molecular Sciences, 2024 - mdpi.com
This review investigates links between post-acute sequelae of SARS-CoV-2 infection
(PASC), post-infection viral persistence, mitochondrial involvement and aberrant innate …

Nanoscale cellular organization of viral RNA and proteins in SARS-CoV-2 replication organelles

L Andronov, M Han, Y Zhu, A Balaji, AR Roy… - Nature …, 2024 - nature.com
The SARS-CoV-2 viral infection transforms host cells and produces special organelles in
many ways, and we focus on the replication organelles, the sites of replication of viral …

The promise and reality of new immune profiling technologies

S Suliman, DP Maison, TJ Henrich - Nature Immunology, 2024 - nature.com
This Comment discusses the explosion in innovative systems biology approaches in
infectious disease studies. We outline the numerous challenges associated with these …

Spatiotemporal analysis of lung immune dynamics in lethal Coccidioides posadasii infection

OA Davalos, A Sebastian, NF Leon, MV Rangel… - mBio, 2024 - journals.asm.org
Coccidioidomycosis, or Valley fever, is a lung disease caused by inhalation of Coccidioides
fungi, prevalent in the Southwestern United States, Mexico, and parts of Central and South …

SARS-CoV2 infection in whole lung primarily targets macrophages that display subset-specific responses

TP Vu Manh, C Gouin, J De Wolf, L Jouneau… - Cellular and Molecular …, 2024 - Springer
Deciphering the initial steps of SARS-CoV-2 infection, that influence COVID-19 outcomes, is
challenging because animal models do not always reproduce human biological processes …

Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery

C Koziol-White, E Gebski, G Cao, RA Panettieri Jr - Respiratory Research, 2024 - Springer
Abstract Precision Cut Lung Slices (PCLS) have emerged as a sophisticated and
physiologically relevant ex vivo model for studying the intricacies of lung diseases, including …

Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and …

S Dror, S Lucotti, T Asao, J Li, I Wortzel… - Research …, 2024 - pmc.ncbi.nlm.nih.gov
Extracellular vesicles and particles (EVPs) are pivotal mediators of pre-metastatic niche
formation and cancer progression, including induction of vascular permeability, which …

Computational Modeling of Transformations of Epidemic Waves of BA. 2.86/JN. 1 SAR-COV-2 Coronavirus Variants on the Basis of Hybrid Oscillators

AY Perevaryukha - Technical Physics, 2024 - Springer
We are developing a modeling method for oscillating processes in biophysics with
discontinuous nonlinearities on the basis of logic of impulse perturbations and equations …

IL-1β-driven NF-κB transcription of ACE2 as a Mechanism of Macrophage Infection by SARS-CoV-2

C Lee, R Khan, CS Mantsounga, S Sharma, J Pierce… - bioRxiv, 2024 - biorxiv.org
Coronavirus disease 2019 (COVID-19), caused by infection with the enveloped RNA
betacoronavirus, SARS-CoV-2, led to a global pandemic involving over 7 million deaths …