Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct
processes. Although our present understanding is incomplete and there are still great …

Deubiquitylating enzymes (DUBs), act downstream of ubiquitylation. As such, these post-
post-translational modifiers function as the final arbitrators of a protein substrate's …

Autophagy has recently elicited significant attention as a mechanism that either protects or
promotes cell death, although different autophagy pathways, and the cellular context in …

The function of many receptors and transport proteins that reside at the surface of the cell is
regulated by endocytosis and postendocytic trafficking. Modification of receptors and …

Targeting of membrane proteins to their proper destination requires specific mechanisms.
Protein cargos are included in vesicles that bud off a donor organelle and ultimately fuse …

Protein ubiquitination is a dynamic and reversible post‐translational modification that
controls diverse cellular processes in eukaryotes. Ubiquitin‐dependent internalization …

Posttranslational modification by ubiquitin controls multiple cellular functions and is
counteracted by the activities of deubiquitinating enzymes. UBPy (USP8) is a growth …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a
number of epithelial tissues. Abnormalities in ENaC function have been directly linked to …

Introduction: Deubiquitinating-enzymes (DUBs) are key components of the ubiquitin–
proteasome system (UPS). The fundamental role of DUBs is specific removal of ubiquitin …